Abstract
Alexander disease is a progressive neurodegenerative disease, which can present with brainstem lesions with imaging characteristics similar to multifocal low-grade glioma, thus presenting a diagnostic dilemma. The authors report a 6-year-old child presenting with multifocal brainstem lesions subsequently diagnosed to have Alexander disease. In vivo magnetic resonance spectroscopy generated a metabolite profile of the lesion allowing differentiation from low-grade glioma. Magnetic resonance spectroscopy is a powerful tool in the assessment of brainstem lesions and is a useful adjunct to conventional magnetic resonance imaging in the assessment and diagnosis of atypical brain lesions.
| Original language | English |
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| Pages (from-to) | 356-60 |
| Number of pages | 5 |
| Journal | Journal of child neurology |
| Volume | 26 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 1 Mar 2011 |