Macrocyclic Metal Complex-DNA Conjugates for Electrochemical Sensing of Single Nucleobase Changes in DNA

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Macrocyclic Metal Complex-DNA Conjugates for Electrochemical Sensing of Single Nucleobase Changes in DNA. / Duprey, Jean-Louis H. A.; Carr-Smith, James; Horswell, Sarah L.; Kowalski, Jarosław; Tucker, James H. R.

In: Journal of the American Chemical Society, Vol. 138, No. 3, 15.01.2016, p. 746-749.

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@article{ffc198fe0df448749b1e0ced190ce91b,
title = "Macrocyclic Metal Complex-DNA Conjugates for Electrochemical Sensing of Single Nucleobase Changes in DNA",
abstract = "The direct incorporation of macrocyclic cyclidene complexes into DNA via automated synthesis results in a new family of metal-functionalized DNA derivatives that readily demonstrate their utility through the ability of one redox-active copper(II)-containing strand to distinguish electrochemically between all four canonical DNA nucleobases at a single site within a target sequence of DNA.",
author = "Duprey, {Jean-Louis H. A.} and James Carr-Smith and Horswell, {Sarah L.} and Jaros{\l}aw Kowalski and Tucker, {James H. R.}",
year = "2016",
month = jan,
day = "15",
doi = "10.1021/jacs.5b11319",
language = "English",
volume = "138",
pages = "746--749",
journal = "Journal of the American Chemical Society",
issn = "0002-7863",
publisher = "American Chemical Society",
number = "3",

}

RIS

TY - JOUR

T1 - Macrocyclic Metal Complex-DNA Conjugates for Electrochemical Sensing of Single Nucleobase Changes in DNA

AU - Duprey, Jean-Louis H. A.

AU - Carr-Smith, James

AU - Horswell, Sarah L.

AU - Kowalski, Jarosław

AU - Tucker, James H. R.

PY - 2016/1/15

Y1 - 2016/1/15

N2 - The direct incorporation of macrocyclic cyclidene complexes into DNA via automated synthesis results in a new family of metal-functionalized DNA derivatives that readily demonstrate their utility through the ability of one redox-active copper(II)-containing strand to distinguish electrochemically between all four canonical DNA nucleobases at a single site within a target sequence of DNA.

AB - The direct incorporation of macrocyclic cyclidene complexes into DNA via automated synthesis results in a new family of metal-functionalized DNA derivatives that readily demonstrate their utility through the ability of one redox-active copper(II)-containing strand to distinguish electrochemically between all four canonical DNA nucleobases at a single site within a target sequence of DNA.

U2 - 10.1021/jacs.5b11319

DO - 10.1021/jacs.5b11319

M3 - Article

C2 - 26694542

VL - 138

SP - 746

EP - 749

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

SN - 0002-7863

IS - 3

ER -