Macrocyclic Metal Complex-DNA Conjugates for Electrochemical Sensing of Single Nucleobase Changes in DNA

Research output: Contribution to journalArticle

Authors

Colleges, School and Institutes

External organisations

  • Polish Acad Sci

Abstract

The direct incorporation of macrocyclic cyclidene complexes into DNA via automated synthesis results in a new family of metal-functionalized DNA derivatives that readily demonstrate their utility through the ability of one redox-active copper(II)-containing strand to distinguish electrochemically between all four canonical DNA nucleobases at a single site within a target sequence of DNA.

Details

Original languageEnglish
Pages (from-to)746-749
JournalJournal of the American Chemical Society
Volume138
Issue number3
Early online date22 Dec 2015
Publication statusPublished - 15 Jan 2016