Lymphostromal interactions in thymic development and function

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Lymphostromal interactions in thymic development and function. / Anderson, Graham; Jenkinson, Eric.

In: Nature Reviews Immunology, Vol. 1, No. 1, 01.10.2001, p. 31-40.

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@article{f1ac17c398f1400bbb6004bb16b50ea9,
title = "Lymphostromal interactions in thymic development and function",
abstract = "The generation of a peripheral T-cell pool is essential for normal immune system function. CD4+ and CD8+ T cells are produced most efficiently in the thymus, which provides a complexity of discrete cellular microenvironments. Specialized stromal cells, that make up such microenvironments, influence each stage in the maturation programme of immature T-cell precursors. Progress has recently been made in elucidating events that regulate the development of intrathymic microenvironments, as well as mechanisms of thymocyte differentiation. It is becoming increasingly clear that the generation and maintenance of thymic environments that are capable of supporting efficient T-cell development, requires complex interplay between lymphoid and stromal compartments of the thymus.",
author = "Graham Anderson and Eric Jenkinson",
year = "2001",
month = oct,
day = "1",
doi = "10.1038/35095500",
language = "English",
volume = "1",
pages = "31--40",
journal = "Nature Reviews Immunology",
issn = "1474-1733",
publisher = "Nature Publishing Group",
number = "1",

}

RIS

TY - JOUR

T1 - Lymphostromal interactions in thymic development and function

AU - Anderson, Graham

AU - Jenkinson, Eric

PY - 2001/10/1

Y1 - 2001/10/1

N2 - The generation of a peripheral T-cell pool is essential for normal immune system function. CD4+ and CD8+ T cells are produced most efficiently in the thymus, which provides a complexity of discrete cellular microenvironments. Specialized stromal cells, that make up such microenvironments, influence each stage in the maturation programme of immature T-cell precursors. Progress has recently been made in elucidating events that regulate the development of intrathymic microenvironments, as well as mechanisms of thymocyte differentiation. It is becoming increasingly clear that the generation and maintenance of thymic environments that are capable of supporting efficient T-cell development, requires complex interplay between lymphoid and stromal compartments of the thymus.

AB - The generation of a peripheral T-cell pool is essential for normal immune system function. CD4+ and CD8+ T cells are produced most efficiently in the thymus, which provides a complexity of discrete cellular microenvironments. Specialized stromal cells, that make up such microenvironments, influence each stage in the maturation programme of immature T-cell precursors. Progress has recently been made in elucidating events that regulate the development of intrathymic microenvironments, as well as mechanisms of thymocyte differentiation. It is becoming increasingly clear that the generation and maintenance of thymic environments that are capable of supporting efficient T-cell development, requires complex interplay between lymphoid and stromal compartments of the thymus.

UR - http://www.scopus.com/inward/record.url?scp=0035496231&partnerID=8YFLogxK

U2 - 10.1038/35095500

DO - 10.1038/35095500

M3 - Article

C2 - 11905812

VL - 1

SP - 31

EP - 40

JO - Nature Reviews Immunology

JF - Nature Reviews Immunology

SN - 1474-1733

IS - 1

ER -