Lymphoid tissue inducer cells: bridges between the ancient innate and the modern adaptive immune systems

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@article{7fde703647ec4d5aa9a105bae88ca4ac,
title = "Lymphoid tissue inducer cells: bridges between the ancient innate and the modern adaptive immune systems",
abstract = "Phylogeny indicates that adaptive immunity evolved first in diffusely distributed lymphoid tissues found in the lamina propria (LP) of the gut. B follicular structures appeared later, probably initially in isolated lymphoid follicles in the LP and then in organized lymphoid tissues such as lymph nodes and Peyer's patches. The development of these new lymphoid structures was enabled by gene duplication and evolution of new tumor necrosis family members. Here, we argue that lymphoid tissue inducer cells (LTis) had a pivotal role, not only in the development of organized lymphoid structures, but also in the subsequent genesis of the CD4-dependent class-switched memory antibody responses. In this review, we concentrate on the latter function: the sustenance by LTis of CD4 T-cell responses for protective immunity.",
author = "Peter Lane and Fiona McConnell and David Withers and Fabrina Gaspal and Manoj Saini and Graham Anderson",
year = "2009",
month = nov,
day = "1",
doi = "10.1038/mi.2009.111",
language = "English",
volume = "2",
pages = "472--7",
journal = "Mucosal immunology",
issn = "1933-0219",
publisher = "Nature Publishing Group",
number = "6",

}

RIS

TY - JOUR

T1 - Lymphoid tissue inducer cells: bridges between the ancient innate and the modern adaptive immune systems

AU - Lane, Peter

AU - McConnell, Fiona

AU - Withers, David

AU - Gaspal, Fabrina

AU - Saini, Manoj

AU - Anderson, Graham

PY - 2009/11/1

Y1 - 2009/11/1

N2 - Phylogeny indicates that adaptive immunity evolved first in diffusely distributed lymphoid tissues found in the lamina propria (LP) of the gut. B follicular structures appeared later, probably initially in isolated lymphoid follicles in the LP and then in organized lymphoid tissues such as lymph nodes and Peyer's patches. The development of these new lymphoid structures was enabled by gene duplication and evolution of new tumor necrosis family members. Here, we argue that lymphoid tissue inducer cells (LTis) had a pivotal role, not only in the development of organized lymphoid structures, but also in the subsequent genesis of the CD4-dependent class-switched memory antibody responses. In this review, we concentrate on the latter function: the sustenance by LTis of CD4 T-cell responses for protective immunity.

AB - Phylogeny indicates that adaptive immunity evolved first in diffusely distributed lymphoid tissues found in the lamina propria (LP) of the gut. B follicular structures appeared later, probably initially in isolated lymphoid follicles in the LP and then in organized lymphoid tissues such as lymph nodes and Peyer's patches. The development of these new lymphoid structures was enabled by gene duplication and evolution of new tumor necrosis family members. Here, we argue that lymphoid tissue inducer cells (LTis) had a pivotal role, not only in the development of organized lymphoid structures, but also in the subsequent genesis of the CD4-dependent class-switched memory antibody responses. In this review, we concentrate on the latter function: the sustenance by LTis of CD4 T-cell responses for protective immunity.

U2 - 10.1038/mi.2009.111

DO - 10.1038/mi.2009.111

M3 - Article

C2 - 19741599

VL - 2

SP - 472

EP - 477

JO - Mucosal immunology

JF - Mucosal immunology

SN - 1933-0219

IS - 6

ER -