TY - JOUR
T1 - Lymphocyte sub-population cell counts are associated with the metabolic syndrome and its components in the Vietnam Experience Study.
AU - Phillips, Anna
AU - Carroll, Douglas
AU - Gale, CR
AU - Drayson, Mark
AU - Thomas, Graham
AU - Batty, GD
PY - 2010/8/19
Y1 - 2010/8/19
N2 - OBJECTIVE: The metabolic syndrome (MetS) increases the risk of cardiovascular disease morbidity and mortality. MetS is also associated with increases in the number of circulating white blood cells. Lymphocyte sub-population counts have also been implicated in cardiovascular disease; this analysis will examine whether or not they are associated with MetS. METHODS: Participants were 4255 Vietnam-era US veterans. From military service files, telephone interviews, and a medical examination, occupational, socio-demographic, and health data were collected. MetS was ascertained from: body mass index; fasting blood glucose or a diabetes medication; blood pressure or a diagnosis of hypertension; HDL cholesterol; and triglyceride levels. Circulating T, T4, T8 and B lymphocytes cell numbers were determined by flow cytometry. RESULTS: In fully adjusted logistic regression analyses, high lymphocyte sub-population counts were associated with an increased risk of MetS: T cells, OR=2.68, 95%CI 1.99-3.61, p
AB - OBJECTIVE: The metabolic syndrome (MetS) increases the risk of cardiovascular disease morbidity and mortality. MetS is also associated with increases in the number of circulating white blood cells. Lymphocyte sub-population counts have also been implicated in cardiovascular disease; this analysis will examine whether or not they are associated with MetS. METHODS: Participants were 4255 Vietnam-era US veterans. From military service files, telephone interviews, and a medical examination, occupational, socio-demographic, and health data were collected. MetS was ascertained from: body mass index; fasting blood glucose or a diabetes medication; blood pressure or a diagnosis of hypertension; HDL cholesterol; and triglyceride levels. Circulating T, T4, T8 and B lymphocytes cell numbers were determined by flow cytometry. RESULTS: In fully adjusted logistic regression analyses, high lymphocyte sub-population counts were associated with an increased risk of MetS: T cells, OR=2.68, 95%CI 1.99-3.61, p
U2 - 10.1016/j.atherosclerosis.2010.08.047
DO - 10.1016/j.atherosclerosis.2010.08.047
M3 - Article
C2 - 20833394
JO - Atherosclerosis
JF - Atherosclerosis
ER -
