Lymph node stroma join the cancer support network

Research output: Contribution to journalComment/debate

Authors

Colleges, School and Institutes

External organisations

  • Monash Univ

Abstract

Lymph nodes (LNs) are sentinels of the immune system. They allow the lymph draining from peripheral tissues to pass through a leucocytic filter, bringing lymph-borne antigens, inflammatory mediators and antigen presenting cells into close proximity with immune cells capable of responding to antigen exposure. Although LNs are often the first site of tumour metastasis for many cancers, it remains unclear how tumour development affects LN structure and function, and how these changes in turn drive tumour growth.

Details

Original languageEnglish
Pages (from-to)1899-1901
JournalCell Death & Differentiation
Volume23
Issue number12
Publication statusPublished - Dec 2016