Lymph node stroma join the cancer support network
Research output: Contribution to journal › Comment/debate › peer-review
Colleges, School and Institutes
- Monash University
Lymph nodes (LNs) are sentinels of the immune system. They allow the lymph draining from peripheral tissues to pass through a leucocytic filter, bringing lymph-borne antigens, inflammatory mediators and antigen presenting cells into close proximity with immune cells capable of responding to antigen exposure. Although LNs are often the first site of tumour metastasis for many cancers, it remains unclear how tumour development affects LN structure and function, and how these changes in turn drive tumour growth.