Ly49H(+) NK cells migrate to and protect splenic white pulp stroma from murine cytomegalovirus infection

Research output: Contribution to journalArticle

Standard

Harvard

APA

Vancouver

Author

Bibtex

@article{62b70479331c4c17b5da0bbe5636c802,
title = "Ly49H(+) NK cells migrate to and protect splenic white pulp stroma from murine cytomegalovirus infection",
abstract = "In this study, we show that in the absence of a protective NK cell response, murine CMV causes destruction of splenic white and red pulp pulp areas in the first few days of infection. Destruction of T zone stroma is associated with almost complete loss of dendritic cells and T cells. We provide evidence that the virus replicates in red and white pulp stroma in vivo and in vitro. Control of white pulp viral replication is associated with migration of murine CMV-specific activated NK cells to white pulp areas, where they associate directly with podoplanin-expressing T zone stromal cells. Our data explain how NK cells protect the lymphoid-rich white pulp areas from CMV, allowing protective adaptive T cell-dependent immune responses to develop, and how this mechanism might breakdown in immunocompromised patients.",
author = "Vasileios Bekiaris and Olga Timoshenko and Tiezheng Hou and Kai-Michael Toellner and S Shakib and Fabrina Gaspal and Fiona McConnell and SM Parnell and David Withers and Christopher Buckley and Clive Sweet and WM Yokoyama and Graham Anderson and Peter Lane",
year = "2008",
month = jan,
day = "1",
doi = "10.4049/​jimmunol.180.10.6768",
language = "English",
volume = "180",
pages = "6768--6776",
journal = "Journal of Immunology",
issn = "0022-1767",
publisher = "American Association of Immunologists",
number = "10",

}

RIS

TY - JOUR

T1 - Ly49H(+) NK cells migrate to and protect splenic white pulp stroma from murine cytomegalovirus infection

AU - Bekiaris, Vasileios

AU - Timoshenko, Olga

AU - Hou, Tiezheng

AU - Toellner, Kai-Michael

AU - Shakib, S

AU - Gaspal, Fabrina

AU - McConnell, Fiona

AU - Parnell, SM

AU - Withers, David

AU - Buckley, Christopher

AU - Sweet, Clive

AU - Yokoyama, WM

AU - Anderson, Graham

AU - Lane, Peter

PY - 2008/1/1

Y1 - 2008/1/1

N2 - In this study, we show that in the absence of a protective NK cell response, murine CMV causes destruction of splenic white and red pulp pulp areas in the first few days of infection. Destruction of T zone stroma is associated with almost complete loss of dendritic cells and T cells. We provide evidence that the virus replicates in red and white pulp stroma in vivo and in vitro. Control of white pulp viral replication is associated with migration of murine CMV-specific activated NK cells to white pulp areas, where they associate directly with podoplanin-expressing T zone stromal cells. Our data explain how NK cells protect the lymphoid-rich white pulp areas from CMV, allowing protective adaptive T cell-dependent immune responses to develop, and how this mechanism might breakdown in immunocompromised patients.

AB - In this study, we show that in the absence of a protective NK cell response, murine CMV causes destruction of splenic white and red pulp pulp areas in the first few days of infection. Destruction of T zone stroma is associated with almost complete loss of dendritic cells and T cells. We provide evidence that the virus replicates in red and white pulp stroma in vivo and in vitro. Control of white pulp viral replication is associated with migration of murine CMV-specific activated NK cells to white pulp areas, where they associate directly with podoplanin-expressing T zone stromal cells. Our data explain how NK cells protect the lymphoid-rich white pulp areas from CMV, allowing protective adaptive T cell-dependent immune responses to develop, and how this mechanism might breakdown in immunocompromised patients.

U2 - 10.4049/​jimmunol.180.10.6768

DO - 10.4049/​jimmunol.180.10.6768

M3 - Article

C2 - 18453597

VL - 180

SP - 6768

EP - 6776

JO - Journal of Immunology

JF - Journal of Immunology

SN - 0022-1767

IS - 10

ER -