Low-grade inflammation decreases emotion recognition - evidence from the vaccination model of inflammation

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@article{e2e074bd8b3144308c11a2260741662d,
title = "Low-grade inflammation decreases emotion recognition - evidence from the vaccination model of inflammation",
abstract = "The ability to adequately interpret the mental state of another person is key to complex human social interaction. Recent evidence suggests that this ability, considered a hallmark of 'theory of mind' (ToM), becomes impaired by inflammation. However, extant supportive empirical evidence is based on experiments that induce not only inflammation but also induce discomfort and sickness, factors that could also account for temporary social impairment. Hence, an experimental inflammation manipulation was applied that avoided this confound, isolating effects of inflammation and social interaction. Forty healthy male participants (mean age = 25, SD = 5 years) participated in this double-blind placebo-controlled crossover trial. Inflammation was induced using Salmonella Typhi vaccination (0.025 mg; Typhim Vi, Sanofi Pasteur, UK); saline-injection was used as a control. About 6h30m after injection in each condition, participants completed the Reading the Mind in the Eyes Test (RMET), a validated test for assessing how well the mental states of others can be inferred through observation of the eyes region of the face. Vaccination induced systemic inflammation, elevating IL-6 by +419% (p < .001), without fever, sickness symptoms (e.g., nausea, light-headedness), or mood changes (all p's > .21). Importantly, compared to placebo, vaccination significantly reduced RMET accuracy (p < .05). RMET stimuli selected on valence (positive, negative, neutral) provided no evidence of a selective impact of treatment. By utilizing an inflammation-induction procedure that avoided concurrent sicknesses or symptoms in a double-blinded design, the present study provides further support for the hypothesis that immune activation impairs ToM. Such impairment may provide a mechanistic link explaining social-cognitive deficits in psychopathologies that exhibit low-grade inflammation, such as major depression.",
keywords = "inflammation, social cognition, sickness behaviour, typhoid vaccination, cytokines reading the mind in the eyes, theory of mind, psychoneuroimmunology",
author = "Leonie Balter and Sasha Hulsken and Sarah Aldred and Mark Drayson and Suzanne Higgs and {Veldhuijzen van Zanten}, Joachimina and Jane Raymond and Jos Bosch",
note = "Copyright {\textcopyright} 2018. Published by Elsevier Inc.",
year = "2018",
month = oct
doi = "10.1016/j.bbi.2018.05.006",
language = "English",
pages = "216",
journal = "Brain, Behaviour, and Immunity",
issn = "0889-1591",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Low-grade inflammation decreases emotion recognition - evidence from the vaccination model of inflammation

AU - Balter, Leonie

AU - Hulsken, Sasha

AU - Aldred, Sarah

AU - Drayson, Mark

AU - Higgs, Suzanne

AU - Veldhuijzen van Zanten, Joachimina

AU - Raymond, Jane

AU - Bosch, Jos

N1 - Copyright © 2018. Published by Elsevier Inc.

PY - 2018/10

Y1 - 2018/10

N2 - The ability to adequately interpret the mental state of another person is key to complex human social interaction. Recent evidence suggests that this ability, considered a hallmark of 'theory of mind' (ToM), becomes impaired by inflammation. However, extant supportive empirical evidence is based on experiments that induce not only inflammation but also induce discomfort and sickness, factors that could also account for temporary social impairment. Hence, an experimental inflammation manipulation was applied that avoided this confound, isolating effects of inflammation and social interaction. Forty healthy male participants (mean age = 25, SD = 5 years) participated in this double-blind placebo-controlled crossover trial. Inflammation was induced using Salmonella Typhi vaccination (0.025 mg; Typhim Vi, Sanofi Pasteur, UK); saline-injection was used as a control. About 6h30m after injection in each condition, participants completed the Reading the Mind in the Eyes Test (RMET), a validated test for assessing how well the mental states of others can be inferred through observation of the eyes region of the face. Vaccination induced systemic inflammation, elevating IL-6 by +419% (p < .001), without fever, sickness symptoms (e.g., nausea, light-headedness), or mood changes (all p's > .21). Importantly, compared to placebo, vaccination significantly reduced RMET accuracy (p < .05). RMET stimuli selected on valence (positive, negative, neutral) provided no evidence of a selective impact of treatment. By utilizing an inflammation-induction procedure that avoided concurrent sicknesses or symptoms in a double-blinded design, the present study provides further support for the hypothesis that immune activation impairs ToM. Such impairment may provide a mechanistic link explaining social-cognitive deficits in psychopathologies that exhibit low-grade inflammation, such as major depression.

AB - The ability to adequately interpret the mental state of another person is key to complex human social interaction. Recent evidence suggests that this ability, considered a hallmark of 'theory of mind' (ToM), becomes impaired by inflammation. However, extant supportive empirical evidence is based on experiments that induce not only inflammation but also induce discomfort and sickness, factors that could also account for temporary social impairment. Hence, an experimental inflammation manipulation was applied that avoided this confound, isolating effects of inflammation and social interaction. Forty healthy male participants (mean age = 25, SD = 5 years) participated in this double-blind placebo-controlled crossover trial. Inflammation was induced using Salmonella Typhi vaccination (0.025 mg; Typhim Vi, Sanofi Pasteur, UK); saline-injection was used as a control. About 6h30m after injection in each condition, participants completed the Reading the Mind in the Eyes Test (RMET), a validated test for assessing how well the mental states of others can be inferred through observation of the eyes region of the face. Vaccination induced systemic inflammation, elevating IL-6 by +419% (p < .001), without fever, sickness symptoms (e.g., nausea, light-headedness), or mood changes (all p's > .21). Importantly, compared to placebo, vaccination significantly reduced RMET accuracy (p < .05). RMET stimuli selected on valence (positive, negative, neutral) provided no evidence of a selective impact of treatment. By utilizing an inflammation-induction procedure that avoided concurrent sicknesses or symptoms in a double-blinded design, the present study provides further support for the hypothesis that immune activation impairs ToM. Such impairment may provide a mechanistic link explaining social-cognitive deficits in psychopathologies that exhibit low-grade inflammation, such as major depression.

KW - inflammation

KW - social cognition

KW - sickness behaviour

KW - typhoid vaccination

KW - cytokines reading the mind in the eyes

KW - theory of mind

KW - psychoneuroimmunology

U2 - 10.1016/j.bbi.2018.05.006

DO - 10.1016/j.bbi.2018.05.006

M3 - Article

C2 - 29742460

SP - 216

JO - Brain, Behaviour, and Immunity

JF - Brain, Behaviour, and Immunity

SN - 0889-1591

ER -