TY - JOUR
T1 - Low energy diet and intracranial pressure in women with idiopathic intracranial hypertension:
T2 - prospective cohort study
AU - Sinclair, Alexandra
AU - Burdon, Michael A.
AU - Nightingale, Peter
AU - Ball, Alexandra
AU - Good, Peter
AU - Matthews, Timothy D.
AU - Jacks, Andrew
AU - Lawden, Mark
AU - Clarke, Carl
AU - Stewart, Paul
AU - Walker, Elizabeth
AU - Tomlinson, Jeremy
AU - Rauz, Saaeha
PY - 2010/7/1
Y1 - 2010/7/1
N2 - Objective To observe intracranial pressure in women with idiopathic intracranial hypertension who follow a low energy diet.
Design Prospective cohort study.
Setting Outpatient department and the clinical research facility based at two separate hospitals within the United Kingdom.
Participants 25 women with body mass index (BMI) > 25, with active (papilloedema and intracranial pressure > 25 cm H2O), chronic (over three months) idiopathic intracranial hypertension. Women who had undergone surgery to treat idiopathic intracranial hypertension were excluded.
Intervention Stage 1: no new intervention; stage 2: nutritionally complete low energy (calorie) diet (1777 kJ/day (425 kcal/day)); stage 3: follow-up period after the diet. Each stage lasted three months.
Main outcome measure The primary outcome was reduction in intracranial pressure after the diet. Secondary measures included score on headache impact test-6, papilloedema (as measured by ultrasonography of the elevation of the optic disc and diameter of the nerve sheath, together with thickness of the peripapillary retina measured by optical coherence tomography), mean deviation of Humphrey visual field, LogMAR visual acuity, and symptoms. Outcome measures were assessed at baseline and three, six, and nine months. Lumbar puncture, to quantify intracranial pressure, was measured at baseline and three and six months.
Results All variables remained stable over stage 1. During stage 2, there were significant reductions in weight (mean 15.7 (SD 8.0) kg, P
AB - Objective To observe intracranial pressure in women with idiopathic intracranial hypertension who follow a low energy diet.
Design Prospective cohort study.
Setting Outpatient department and the clinical research facility based at two separate hospitals within the United Kingdom.
Participants 25 women with body mass index (BMI) > 25, with active (papilloedema and intracranial pressure > 25 cm H2O), chronic (over three months) idiopathic intracranial hypertension. Women who had undergone surgery to treat idiopathic intracranial hypertension were excluded.
Intervention Stage 1: no new intervention; stage 2: nutritionally complete low energy (calorie) diet (1777 kJ/day (425 kcal/day)); stage 3: follow-up period after the diet. Each stage lasted three months.
Main outcome measure The primary outcome was reduction in intracranial pressure after the diet. Secondary measures included score on headache impact test-6, papilloedema (as measured by ultrasonography of the elevation of the optic disc and diameter of the nerve sheath, together with thickness of the peripapillary retina measured by optical coherence tomography), mean deviation of Humphrey visual field, LogMAR visual acuity, and symptoms. Outcome measures were assessed at baseline and three, six, and nine months. Lumbar puncture, to quantify intracranial pressure, was measured at baseline and three and six months.
Results All variables remained stable over stage 1. During stage 2, there were significant reductions in weight (mean 15.7 (SD 8.0) kg, P
U2 - 10.1136/bmj.c2701
DO - 10.1136/bmj.c2701
M3 - Article
C2 - 20610512
SN - 1756-1833
VL - 341
JO - British Medical Journal (International edition)
JF - British Medical Journal (International edition)
IS - Jul 07
M1 - c2701
ER -