Low CD4 T cell immunity to pneumolysin is associated with nasopharyngeal carriage of pneumococci in children

Research output: Contribution to journalArticlepeer-review

Authors

  • Qibo Zhang
  • Linda Bagrade
  • Jolanta Bernatoniene
  • Ed Clarke
  • James C Paton
  • Desmond A Nunez
  • Adam Finn

Colleges, School and Institutes

Abstract

Recent studies in mice have suggested that T cell immunity may be protective against pneumococcal infection.

Details

Original languageEnglish
Pages (from-to)1194-202
Number of pages9
JournalThe Journal of Infectious Diseases
Volume195
Issue number8
Publication statusPublished - 15 Apr 2007

Keywords

  • Antibodies, Bacterial, Bacterial Proteins, CD4-Positive T-Lymphocytes, Carrier State, Cell Proliferation, Cells, Cultured, Child, Child, Preschool, Female, Humans, Interferon-gamma, Male, Nasopharynx, Pneumococcal Infections, Streptococcus pneumoniae, Streptolysins, Time Factors, Toll-Like Receptors, Tumor Necrosis Factor-alpha