Loss of CRMP2 O-GlcNAcylation leads to reduced novel object recognition performance in mice

Research output: Contribution to journalArticlepeer-review

Standard

Loss of CRMP2 O-GlcNAcylation leads to reduced novel object recognition performance in mice. / Muha, Villo; Williamson, Ritchie; Hills, Rachel; McNeilly, Alison D.; McWilliams, Thomas G.; Alonso, Jana; Schimpl, Marianne; Leney, Aneika C.; Heck, Albert J.R.; Sutherland, Calum; Read, Kevin D.; McCrimmon, Rory J.; Brooks, Simon P.; Van Aalten, Daan M.F.

In: Open Biology, Vol. 9, No. 11, 190192, 27.11.2019, p. 1-15.

Research output: Contribution to journalArticlepeer-review

Harvard

Muha, V, Williamson, R, Hills, R, McNeilly, AD, McWilliams, TG, Alonso, J, Schimpl, M, Leney, AC, Heck, AJR, Sutherland, C, Read, KD, McCrimmon, RJ, Brooks, SP & Van Aalten, DMF 2019, 'Loss of CRMP2 O-GlcNAcylation leads to reduced novel object recognition performance in mice', Open Biology, vol. 9, no. 11, 190192, pp. 1-15. https://doi.org/10.1098/rsob.190192

APA

Muha, V., Williamson, R., Hills, R., McNeilly, A. D., McWilliams, T. G., Alonso, J., Schimpl, M., Leney, A. C., Heck, A. J. R., Sutherland, C., Read, K. D., McCrimmon, R. J., Brooks, S. P., & Van Aalten, D. M. F. (2019). Loss of CRMP2 O-GlcNAcylation leads to reduced novel object recognition performance in mice. Open Biology, 9(11), 1-15. [190192]. https://doi.org/10.1098/rsob.190192

Vancouver

Muha V, Williamson R, Hills R, McNeilly AD, McWilliams TG, Alonso J et al. Loss of CRMP2 O-GlcNAcylation leads to reduced novel object recognition performance in mice. Open Biology. 2019 Nov 27;9(11):1-15. 190192. https://doi.org/10.1098/rsob.190192

Author

Muha, Villo ; Williamson, Ritchie ; Hills, Rachel ; McNeilly, Alison D. ; McWilliams, Thomas G. ; Alonso, Jana ; Schimpl, Marianne ; Leney, Aneika C. ; Heck, Albert J.R. ; Sutherland, Calum ; Read, Kevin D. ; McCrimmon, Rory J. ; Brooks, Simon P. ; Van Aalten, Daan M.F. / Loss of CRMP2 O-GlcNAcylation leads to reduced novel object recognition performance in mice. In: Open Biology. 2019 ; Vol. 9, No. 11. pp. 1-15.

Bibtex

@article{9d831fe7fe4242b9b170987db8af35d4,
title = "Loss of CRMP2 O-GlcNAcylation leads to reduced novel object recognition performance in mice",
abstract = "O-GlcNAcylation is an abundant post-translational modification in the nervous system, linked to both neurodevelopmental and neurodegenerative disease. However, the mechanistic links between these phenotypes and site-specific O-GlcNAcylation remain largely unexplored. Here, we show that Ser517 O-GlcNAcylation of the microtubule-binding protein Collapsin Response Mediator Protein-2 (CRMP2) increases with age. By generating and characterizing a Crmp2S517A knock-in mouse model, we demonstrate that loss of O-GlcNAcylation leads to a small decrease in body weight and mild memory impairment, suggesting that Ser517 O-GlcNAcylation has a small but detectable impact on mouse physiology and cognitive function.",
keywords = "cognitive function, CRMP2, crosstalk, O-GlcNAcylation",
author = "Villo Muha and Ritchie Williamson and Rachel Hills and McNeilly, {Alison D.} and McWilliams, {Thomas G.} and Jana Alonso and Marianne Schimpl and Leney, {Aneika C.} and Heck, {Albert J.R.} and Calum Sutherland and Read, {Kevin D.} and McCrimmon, {Rory J.} and Brooks, {Simon P.} and {Van Aalten}, {Daan M.F.}",
year = "2019",
month = nov,
day = "27",
doi = "10.1098/rsob.190192",
language = "English",
volume = "9",
pages = "1--15",
journal = "Open Biology",
issn = "2046-2441",
publisher = "The Royal Society",
number = "11",

}

RIS

TY - JOUR

T1 - Loss of CRMP2 O-GlcNAcylation leads to reduced novel object recognition performance in mice

AU - Muha, Villo

AU - Williamson, Ritchie

AU - Hills, Rachel

AU - McNeilly, Alison D.

AU - McWilliams, Thomas G.

AU - Alonso, Jana

AU - Schimpl, Marianne

AU - Leney, Aneika C.

AU - Heck, Albert J.R.

AU - Sutherland, Calum

AU - Read, Kevin D.

AU - McCrimmon, Rory J.

AU - Brooks, Simon P.

AU - Van Aalten, Daan M.F.

PY - 2019/11/27

Y1 - 2019/11/27

N2 - O-GlcNAcylation is an abundant post-translational modification in the nervous system, linked to both neurodevelopmental and neurodegenerative disease. However, the mechanistic links between these phenotypes and site-specific O-GlcNAcylation remain largely unexplored. Here, we show that Ser517 O-GlcNAcylation of the microtubule-binding protein Collapsin Response Mediator Protein-2 (CRMP2) increases with age. By generating and characterizing a Crmp2S517A knock-in mouse model, we demonstrate that loss of O-GlcNAcylation leads to a small decrease in body weight and mild memory impairment, suggesting that Ser517 O-GlcNAcylation has a small but detectable impact on mouse physiology and cognitive function.

AB - O-GlcNAcylation is an abundant post-translational modification in the nervous system, linked to both neurodevelopmental and neurodegenerative disease. However, the mechanistic links between these phenotypes and site-specific O-GlcNAcylation remain largely unexplored. Here, we show that Ser517 O-GlcNAcylation of the microtubule-binding protein Collapsin Response Mediator Protein-2 (CRMP2) increases with age. By generating and characterizing a Crmp2S517A knock-in mouse model, we demonstrate that loss of O-GlcNAcylation leads to a small decrease in body weight and mild memory impairment, suggesting that Ser517 O-GlcNAcylation has a small but detectable impact on mouse physiology and cognitive function.

KW - cognitive function

KW - CRMP2

KW - crosstalk

KW - O-GlcNAcylation

UR - http://www.scopus.com/inward/record.url?scp=85075658823&partnerID=8YFLogxK

U2 - 10.1098/rsob.190192

DO - 10.1098/rsob.190192

M3 - Article

C2 - 31771416

AN - SCOPUS:85075658823

VL - 9

SP - 1

EP - 15

JO - Open Biology

JF - Open Biology

SN - 2046-2441

IS - 11

M1 - 190192

ER -