Loss of CD151/Tspan24 from the complex with integrin α3β1 in invasive front of the tumour is a negative predictor of disease-free survival in oral squamous cell carcinoma

Research output: Contribution to journalArticlepeer-review

Authors

  • P Potemski
  • S I Collins
  • H Williams
  • S Parmar

Colleges, School and Institutes

Abstract

The study aimed to assess the role of CD151-integrin α3β1 (INGA3) complex as a potential prognostic indicator in OSCC and to examine whether mapping of its expression in the invasive front separately from that in the rest of the tumour would have an impact on the predictive value of the results. CD151/INGA3 profiles were compared with that of EGFR.

Bibliographic note

Copyright © 2012 Elsevier Ltd. All rights reserved.

Details

Original languageEnglish
Pages (from-to)224-9
Number of pages6
JournalOral Oncology
Volume49
Issue number3
Publication statusPublished - Mar 2013

Keywords

  • Adolescent, Adult, Aged, Aged, 80 and over, Antigens, CD151, Carcinoma, Squamous Cell, Cohort Studies, Disease-Free Survival, Epithelium, Female, Follow-Up Studies, Humans, Immunohistochemistry, Integrin alpha3, Integrin alpha3beta1, Lymph Nodes, Male, Middle Aged, Mouth Mucosa, Mouth Neoplasms, Neoplasm Grading, Neoplasm Invasiveness, Neoplasm Staging, Predictive Value of Tests, Prognosis, Receptor, Epidermal Growth Factor, Tumor Markers, Biological, Young Adult