Longer-term increased cortisol levels in young people with mental health problems

Research output: Contribution to journalArticlepeer-review

Standard

Longer-term increased cortisol levels in young people with mental health problems. / Heinze, Kareen; Lin, Ashleigh; Reniers, Renate; Wood, Stephen.

In: Psychiatry Research, Vol. 236, 28.02.2016, p. 98-104.

Research output: Contribution to journalArticlepeer-review

Harvard

APA

Vancouver

Author

Bibtex

@article{90fc6689319c465485a0cf41c40b4b82,
title = "Longer-term increased cortisol levels in young people with mental health problems",
abstract = "Disturbance of hypothalamus-pituitary-adrenal axis activity is commonly reported in a range of mental disorders in blood, saliva and urine samples. This study aimed to look at longer-term cortisol levels and their association with clinical symptoms. Hair strands of 30 young people (16-25 years) presenting with mental health problems (Mage±SD=21±2.4, 26 females) and 28 healthy controls (HC, Mage±SD=20±2.9, 26 females) were analyzed for cortisol concentrations, representing the past 6 months prior to hair sampling. Clinical participants completed an assessment on psychiatric symptoms, functioning and lifestyle factors. All participants completed the Perceived Stress Scale. Hair cortisol concentrations representing the past 3 (but not 3-6) months were significantly increased in clinical participants compared to HC. Perceived stress in the past month was significantly higher in clinical participants compared to HC, but not significantly correlated with hair cortisol. Hair cortisol levels were not significantly associated with any other measures. Hair segment analyses revealed longer-term increased levels of cortisol in the past 3 months in early mental health problems. Further insight into the role of cortisol on the pathogenesis of mental illnesses requires longitudinal studies relating cortisol to psychopathology and progression of illness.",
keywords = "hair cortisol, youth mental health, clinical staging",
author = "Kareen Heinze and Ashleigh Lin and Renate Reniers and Stephen Wood",
year = "2016",
month = feb,
day = "28",
doi = "10.1016/j.psychres.2015.12.025",
language = "English",
volume = "236",
pages = "98--104",
journal = "Psychiatry Research",
issn = "0165-1781",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Longer-term increased cortisol levels in young people with mental health problems

AU - Heinze, Kareen

AU - Lin, Ashleigh

AU - Reniers, Renate

AU - Wood, Stephen

PY - 2016/2/28

Y1 - 2016/2/28

N2 - Disturbance of hypothalamus-pituitary-adrenal axis activity is commonly reported in a range of mental disorders in blood, saliva and urine samples. This study aimed to look at longer-term cortisol levels and their association with clinical symptoms. Hair strands of 30 young people (16-25 years) presenting with mental health problems (Mage±SD=21±2.4, 26 females) and 28 healthy controls (HC, Mage±SD=20±2.9, 26 females) were analyzed for cortisol concentrations, representing the past 6 months prior to hair sampling. Clinical participants completed an assessment on psychiatric symptoms, functioning and lifestyle factors. All participants completed the Perceived Stress Scale. Hair cortisol concentrations representing the past 3 (but not 3-6) months were significantly increased in clinical participants compared to HC. Perceived stress in the past month was significantly higher in clinical participants compared to HC, but not significantly correlated with hair cortisol. Hair cortisol levels were not significantly associated with any other measures. Hair segment analyses revealed longer-term increased levels of cortisol in the past 3 months in early mental health problems. Further insight into the role of cortisol on the pathogenesis of mental illnesses requires longitudinal studies relating cortisol to psychopathology and progression of illness.

AB - Disturbance of hypothalamus-pituitary-adrenal axis activity is commonly reported in a range of mental disorders in blood, saliva and urine samples. This study aimed to look at longer-term cortisol levels and their association with clinical symptoms. Hair strands of 30 young people (16-25 years) presenting with mental health problems (Mage±SD=21±2.4, 26 females) and 28 healthy controls (HC, Mage±SD=20±2.9, 26 females) were analyzed for cortisol concentrations, representing the past 6 months prior to hair sampling. Clinical participants completed an assessment on psychiatric symptoms, functioning and lifestyle factors. All participants completed the Perceived Stress Scale. Hair cortisol concentrations representing the past 3 (but not 3-6) months were significantly increased in clinical participants compared to HC. Perceived stress in the past month was significantly higher in clinical participants compared to HC, but not significantly correlated with hair cortisol. Hair cortisol levels were not significantly associated with any other measures. Hair segment analyses revealed longer-term increased levels of cortisol in the past 3 months in early mental health problems. Further insight into the role of cortisol on the pathogenesis of mental illnesses requires longitudinal studies relating cortisol to psychopathology and progression of illness.

KW - hair cortisol

KW - youth mental health

KW - clinical staging

U2 - 10.1016/j.psychres.2015.12.025

DO - 10.1016/j.psychres.2015.12.025

M3 - Article

C2 - 26749569

VL - 236

SP - 98

EP - 104

JO - Psychiatry Research

JF - Psychiatry Research

SN - 0165-1781

ER -