Loneliness in healthy young adults predicts inflammatory responsiveness to a mild immune challenge in vivo

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@article{c0dd50702f0846f8a551141da764330b,
title = "Loneliness in healthy young adults predicts inflammatory responsiveness to a mild immune challenge in vivo",
abstract = "The established link between loneliness and poor health outcomes may stem from aberrant inflammatory regulation. The present study tested whether loneliness predicted the inflammatory response to a standardised in vivo immune challenge. Using a within-subjects double blind placebo-controlled design, 40 healthy men (mean age = 25, SD = 5) received a Salmonella Typhi vaccination (0.025 mg; Typhim Vi, Sanofi Pasteur, UK) and placebo (saline) on two separate occasions. Loneliness was assessed using the R-UCLA loneliness scale. Regression analyses showed that those that reported feeling more lonely exhibited an elevated interleukin-6 response (β = 0.564, 95{\%} confidence interval [0.003, 0.042], p < .05). This association withstood adjustment for potentially confounding variables, including age, sleep quality, socio-emotional factors, and health factors. The present findings are in line with evidence that loneliness may shift immune system responsivity, suggesting a potential biobehavioural pathway linking loneliness to impaired health.",
keywords = "loneliness, mild inflammation, immune dysregulation, typhoid vaccination",
author = "Balter, {Leonie J. T.} and Raymond, {Jane E.} and Sarah Aldred and Drayson, {Mark T.} and {Veldhuijzen van Zanten}, {Jet J. C. S.} and Suzanne Higgs and Bosch, {Jos A.}",
note = "Copyright {\circledC} 2019. Published by Elsevier Inc.",
year = "2019",
month = "8",
day = "30",
doi = "10.1016/j.bbi.2019.08.196",
language = "English",
journal = "Brain, Behaviour, and Immunity",
issn = "0889-1591",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Loneliness in healthy young adults predicts inflammatory responsiveness to a mild immune challenge in vivo

AU - Balter, Leonie J. T.

AU - Raymond, Jane E.

AU - Aldred, Sarah

AU - Drayson, Mark T.

AU - Veldhuijzen van Zanten, Jet J. C. S.

AU - Higgs, Suzanne

AU - Bosch, Jos A.

N1 - Copyright © 2019. Published by Elsevier Inc.

PY - 2019/8/30

Y1 - 2019/8/30

N2 - The established link between loneliness and poor health outcomes may stem from aberrant inflammatory regulation. The present study tested whether loneliness predicted the inflammatory response to a standardised in vivo immune challenge. Using a within-subjects double blind placebo-controlled design, 40 healthy men (mean age = 25, SD = 5) received a Salmonella Typhi vaccination (0.025 mg; Typhim Vi, Sanofi Pasteur, UK) and placebo (saline) on two separate occasions. Loneliness was assessed using the R-UCLA loneliness scale. Regression analyses showed that those that reported feeling more lonely exhibited an elevated interleukin-6 response (β = 0.564, 95% confidence interval [0.003, 0.042], p < .05). This association withstood adjustment for potentially confounding variables, including age, sleep quality, socio-emotional factors, and health factors. The present findings are in line with evidence that loneliness may shift immune system responsivity, suggesting a potential biobehavioural pathway linking loneliness to impaired health.

AB - The established link between loneliness and poor health outcomes may stem from aberrant inflammatory regulation. The present study tested whether loneliness predicted the inflammatory response to a standardised in vivo immune challenge. Using a within-subjects double blind placebo-controlled design, 40 healthy men (mean age = 25, SD = 5) received a Salmonella Typhi vaccination (0.025 mg; Typhim Vi, Sanofi Pasteur, UK) and placebo (saline) on two separate occasions. Loneliness was assessed using the R-UCLA loneliness scale. Regression analyses showed that those that reported feeling more lonely exhibited an elevated interleukin-6 response (β = 0.564, 95% confidence interval [0.003, 0.042], p < .05). This association withstood adjustment for potentially confounding variables, including age, sleep quality, socio-emotional factors, and health factors. The present findings are in line with evidence that loneliness may shift immune system responsivity, suggesting a potential biobehavioural pathway linking loneliness to impaired health.

KW - loneliness

KW - mild inflammation

KW - immune dysregulation

KW - typhoid vaccination

U2 - 10.1016/j.bbi.2019.08.196

DO - 10.1016/j.bbi.2019.08.196

M3 - Article

C2 - 31476413

JO - Brain, Behaviour, and Immunity

JF - Brain, Behaviour, and Immunity

SN - 0889-1591

ER -