Localization of Idd11 is not associated with thymus and nkt cell abnormalities in NOD mice

Thomas C Brodnicki; Anne L Fletcher; Daniel G Pellicci; Stuart P Berzins; Peter McClive; Fiona Quirk; Kylie E Webster; Hamish S Scott; Richard L Boyd; Dale I Godfrey; Grant Morahan

Localization of Idd11 is not associated with thymus and nkt cell abnormalities in NOD mice

Thomas C Brodnicki, Anne L Fletcher, Daniel G Pellicci, Stuart P Berzins, Peter McClive, Fiona Quirk, Kylie E Webster, Hamish S Scott, Richard L Boyd, Dale I Godfrey, Grant Morahan

Immunology and Immunotherapy

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Congenic mouse strains provide a unique resource for genetic dissection and biological characterization of chromosomal regions associated with diabetes progression in the nonobese diabetic (NOD) mouse. Idd11, a mouse diabetes susceptibility locus, was previously localized to a region on chromosome 4. Comparison of a panel of subcongenic NOD mouse strains with different intervals derived from the nondiabetic C57BL/6 (B6) strain now maps Idd11 to an approximately 8-Mb interval. B6-derived intervals protected congenic NOD mice from diabetes onset, even though lymphocytic infiltration of pancreatic islets was similar to that found in NOD mice. In addition, neither thymic structural irregularities nor NKT cell deficiencies were ameliorated in diabetes-resistant congenic NOD mice, indicating that Idd11 does not contribute to these abnormalities, which do not need to be corrected to prevent disease.

Original language	English
Pages (from-to)	3453-7
Number of pages	5
Journal	Diabetes
Volume	54
Issue number	12
Publication status	Published - Dec 2005

Keywords

Animals
Chromosome Mapping
Diabetes Mellitus, Type 1
Genetic Predisposition to Disease
Mice
Mice, Inbred C57BL
Mice, Inbred NOD
Thymus Gland

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Localization of Idd11 is not associated with thymus and nkt cell abnormalities in NOD mice",

abstract = "Congenic mouse strains provide a unique resource for genetic dissection and biological characterization of chromosomal regions associated with diabetes progression in the nonobese diabetic (NOD) mouse. Idd11, a mouse diabetes susceptibility locus, was previously localized to a region on chromosome 4. Comparison of a panel of subcongenic NOD mouse strains with different intervals derived from the nondiabetic C57BL/6 (B6) strain now maps Idd11 to an approximately 8-Mb interval. B6-derived intervals protected congenic NOD mice from diabetes onset, even though lymphocytic infiltration of pancreatic islets was similar to that found in NOD mice. In addition, neither thymic structural irregularities nor NKT cell deficiencies were ameliorated in diabetes-resistant congenic NOD mice, indicating that Idd11 does not contribute to these abnormalities, which do not need to be corrected to prevent disease.",

keywords = "Animals, Chromosome Mapping, Diabetes Mellitus, Type 1, Genetic Predisposition to Disease, Mice, Mice, Inbred C57BL, Mice, Inbred NOD, Thymus Gland",

author = "Brodnicki, {Thomas C} and Fletcher, {Anne L} and Pellicci, {Daniel G} and Berzins, {Stuart P} and Peter McClive and Fiona Quirk and Webster, {Kylie E} and Scott, {Hamish S} and Boyd, {Richard L} and Godfrey, {Dale I} and Grant Morahan",

year = "2005",

month = dec,

language = "English",

volume = "54",

pages = "3453--7",

journal = "Diabetes",

issn = "0012-1797",

publisher = "American Diabetes Association",

number = "12",

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TY - JOUR

T1 - Localization of Idd11 is not associated with thymus and nkt cell abnormalities in NOD mice

AU - Brodnicki, Thomas C

AU - Fletcher, Anne L

AU - Pellicci, Daniel G

AU - Berzins, Stuart P

AU - McClive, Peter

AU - Quirk, Fiona

AU - Webster, Kylie E

AU - Scott, Hamish S

AU - Boyd, Richard L

AU - Godfrey, Dale I

AU - Morahan, Grant

PY - 2005/12

Y1 - 2005/12

N2 - Congenic mouse strains provide a unique resource for genetic dissection and biological characterization of chromosomal regions associated with diabetes progression in the nonobese diabetic (NOD) mouse. Idd11, a mouse diabetes susceptibility locus, was previously localized to a region on chromosome 4. Comparison of a panel of subcongenic NOD mouse strains with different intervals derived from the nondiabetic C57BL/6 (B6) strain now maps Idd11 to an approximately 8-Mb interval. B6-derived intervals protected congenic NOD mice from diabetes onset, even though lymphocytic infiltration of pancreatic islets was similar to that found in NOD mice. In addition, neither thymic structural irregularities nor NKT cell deficiencies were ameliorated in diabetes-resistant congenic NOD mice, indicating that Idd11 does not contribute to these abnormalities, which do not need to be corrected to prevent disease.

AB - Congenic mouse strains provide a unique resource for genetic dissection and biological characterization of chromosomal regions associated with diabetes progression in the nonobese diabetic (NOD) mouse. Idd11, a mouse diabetes susceptibility locus, was previously localized to a region on chromosome 4. Comparison of a panel of subcongenic NOD mouse strains with different intervals derived from the nondiabetic C57BL/6 (B6) strain now maps Idd11 to an approximately 8-Mb interval. B6-derived intervals protected congenic NOD mice from diabetes onset, even though lymphocytic infiltration of pancreatic islets was similar to that found in NOD mice. In addition, neither thymic structural irregularities nor NKT cell deficiencies were ameliorated in diabetes-resistant congenic NOD mice, indicating that Idd11 does not contribute to these abnormalities, which do not need to be corrected to prevent disease.

KW - Animals

KW - Chromosome Mapping

KW - Diabetes Mellitus, Type 1

KW - Genetic Predisposition to Disease

KW - Mice

KW - Mice, Inbred C57BL

KW - Mice, Inbred NOD

KW - Thymus Gland

M3 - Article

C2 - 16306361

SN - 0012-1797

VL - 54

SP - 3453

EP - 3457

JO - Diabetes

JF - Diabetes

IS - 12

ER -

Localization of Idd11 is not associated with thymus and nkt cell abnormalities in NOD mice

Abstract

Keywords

UN SDGs

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