Local and systemic antioxidant capacity in periodontitis and health

Gareth Brock; C Butterworth; John Matthews; Iain Chapple

doi:10.1111/j.1600-051X.2004.00509.x

Local and systemic antioxidant capacity in periodontitis and health

Gareth Brock, C Butterworth, John Matthews, Iain Chapple

Dentistry

Research output: Contribution to journal › Article

206 Citations (Scopus)

Abstract

BACKGROUND: The involvement of reactive oxygen species (ROS) in periodontal pathology is unclear but will be modulated by in vivo antioxidant defence systems. The aim of this cross-sectional study was to determine both local (saliva and gingival crevicular fluid (GCF) and peripheral (plasma and serum) antioxidant capacity in periodontal health and disease. MATERIALS AND METHODS: Twenty non-smoking volunteers with chronic periodontitis were sampled together with twenty age- and sex-matched, non-smoking controls. After overnight fasting, saliva (whole unstimulated and stimulated) and blood were collected. Total antioxidant capacity (TAOC) was determined using a previously reported enhanced chemiluminescence method. RESULTS: GCF antioxidant concentration was significantly lower (p

Original language	English
Pages (from-to)	515-521
Number of pages	7
Journal	Journal of Clinical Periodontology
Volume	31
DOIs	https://doi.org/10.1111/j.1600-051X.2004.00509.x
Publication status	Published - 1 Jan 2004

Keywords

gingival crevicular fluid
plasma
periodontitis
gender
antioxidant

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10.1111/j.1600-051X.2004.00509.x

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T1 - Local and systemic antioxidant capacity in periodontitis and health

AU - Brock, Gareth

AU - Butterworth, C

AU - Matthews, John

AU - Chapple, Iain

PY - 2004/1/1

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N2 - BACKGROUND: The involvement of reactive oxygen species (ROS) in periodontal pathology is unclear but will be modulated by in vivo antioxidant defence systems. The aim of this cross-sectional study was to determine both local (saliva and gingival crevicular fluid (GCF) and peripheral (plasma and serum) antioxidant capacity in periodontal health and disease. MATERIALS AND METHODS: Twenty non-smoking volunteers with chronic periodontitis were sampled together with twenty age- and sex-matched, non-smoking controls. After overnight fasting, saliva (whole unstimulated and stimulated) and blood were collected. Total antioxidant capacity (TAOC) was determined using a previously reported enhanced chemiluminescence method. RESULTS: GCF antioxidant concentration was significantly lower (p

AB - BACKGROUND: The involvement of reactive oxygen species (ROS) in periodontal pathology is unclear but will be modulated by in vivo antioxidant defence systems. The aim of this cross-sectional study was to determine both local (saliva and gingival crevicular fluid (GCF) and peripheral (plasma and serum) antioxidant capacity in periodontal health and disease. MATERIALS AND METHODS: Twenty non-smoking volunteers with chronic periodontitis were sampled together with twenty age- and sex-matched, non-smoking controls. After overnight fasting, saliva (whole unstimulated and stimulated) and blood were collected. Total antioxidant capacity (TAOC) was determined using a previously reported enhanced chemiluminescence method. RESULTS: GCF antioxidant concentration was significantly lower (p

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KW - plasma

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KW - gender

KW - antioxidant

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Local and systemic antioxidant capacity in periodontitis and health

Abstract

Keywords

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