Local and global regulation of transcription initiation in bacteria
Research output: Contribution to journal › Article › peer-review
Standard
Local and global regulation of transcription initiation in bacteria. / Browning, Douglas F; Busby, Stephen J W.
In: Nature Reviews Microbiology, 08.08.2016.Research output: Contribution to journal › Article › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Local and global regulation of transcription initiation in bacteria
AU - Browning, Douglas F
AU - Busby, Stephen J W
PY - 2016/8/8
Y1 - 2016/8/8
N2 - Gene expression in bacteria relies on promoter recognition by the DNA-dependent RNA polymerase and subsequent transcription initiation. Bacterial cells are able to tune their transcriptional programmes to changing environments, through numerous mechanisms that regulate the activity of RNA polymerase, or change the set of promoters to which the RNA polymerase can bind. In this Review, we outline our current understanding of the different factors that direct the regulation of transcription initiation in bacteria, whether by interacting with promoters, with RNA polymerase or with both, and we discuss the diverse molecular mechanisms that are used by these factors to regulate gene expression.
AB - Gene expression in bacteria relies on promoter recognition by the DNA-dependent RNA polymerase and subsequent transcription initiation. Bacterial cells are able to tune their transcriptional programmes to changing environments, through numerous mechanisms that regulate the activity of RNA polymerase, or change the set of promoters to which the RNA polymerase can bind. In this Review, we outline our current understanding of the different factors that direct the regulation of transcription initiation in bacteria, whether by interacting with promoters, with RNA polymerase or with both, and we discuss the diverse molecular mechanisms that are used by these factors to regulate gene expression.
U2 - 10.1038/nrmicro.2016.103
DO - 10.1038/nrmicro.2016.103
M3 - Article
C2 - 27498839
JO - Nature Reviews Microbiology
JF - Nature Reviews Microbiology
SN - 1740-1526
ER -