Local and global regulation of transcription initiation in bacteria

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@article{63f5653842d04e7fbd1b7d48da241a0c,
title = "Local and global regulation of transcription initiation in bacteria",
abstract = "Gene expression in bacteria relies on promoter recognition by the DNA-dependent RNA polymerase and subsequent transcription initiation. Bacterial cells are able to tune their transcriptional programmes to changing environments, through numerous mechanisms that regulate the activity of RNA polymerase, or change the set of promoters to which the RNA polymerase can bind. In this Review, we outline our current understanding of the different factors that direct the regulation of transcription initiation in bacteria, whether by interacting with promoters, with RNA polymerase or with both, and we discuss the diverse molecular mechanisms that are used by these factors to regulate gene expression.",
author = "Browning, {Douglas F} and Busby, {Stephen J W}",
year = "2016",
month = aug
day = "8",
doi = "10.1038/nrmicro.2016.103",
language = "English",
journal = "Nature Reviews Microbiology",
issn = "1740-1526",
publisher = "Nature Publishing Group",

}

RIS

TY - JOUR

T1 - Local and global regulation of transcription initiation in bacteria

AU - Browning, Douglas F

AU - Busby, Stephen J W

PY - 2016/8/8

Y1 - 2016/8/8

N2 - Gene expression in bacteria relies on promoter recognition by the DNA-dependent RNA polymerase and subsequent transcription initiation. Bacterial cells are able to tune their transcriptional programmes to changing environments, through numerous mechanisms that regulate the activity of RNA polymerase, or change the set of promoters to which the RNA polymerase can bind. In this Review, we outline our current understanding of the different factors that direct the regulation of transcription initiation in bacteria, whether by interacting with promoters, with RNA polymerase or with both, and we discuss the diverse molecular mechanisms that are used by these factors to regulate gene expression.

AB - Gene expression in bacteria relies on promoter recognition by the DNA-dependent RNA polymerase and subsequent transcription initiation. Bacterial cells are able to tune their transcriptional programmes to changing environments, through numerous mechanisms that regulate the activity of RNA polymerase, or change the set of promoters to which the RNA polymerase can bind. In this Review, we outline our current understanding of the different factors that direct the regulation of transcription initiation in bacteria, whether by interacting with promoters, with RNA polymerase or with both, and we discuss the diverse molecular mechanisms that are used by these factors to regulate gene expression.

U2 - 10.1038/nrmicro.2016.103

DO - 10.1038/nrmicro.2016.103

M3 - Article

C2 - 27498839

JO - Nature Reviews Microbiology

JF - Nature Reviews Microbiology

SN - 1740-1526

ER -