LMP1 structure and signal transduction

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Colleges, School and Institutes

Abstract

The oncogenic Epstein-Barr virus (EBV)-encoded latent membrane protein 1 (LMP1) has structural features and functions reminiscent of a constitutively active TNF family receptor. LMP1 aggregates at the plasma membrane and initiates the activation of signalling pathways, such as NF- kappa B, the mitogen-activated protein kinases JNK and p38, the small GTPase Cdc42 and the JAK/STAT cascade. The constitutive engagement of these signals and the characteristic molecular interactions that regulate them provide the basis for the molecular explanation of the transforming properties of this key EBV protein.

Details

Original languageEnglish
Pages (from-to)435-444
Number of pages10
JournalSeminars in Cancer Biology
Volume11
Issue number6
Publication statusPublished - 1 Dec 2001

Keywords

  • LMP1, EBV, CD40, signalling