Liver stem cells: plasticity of the liver epithelium

Research output: Contribution to journalReview articlepeer-review


Colleges, School and Institutes

External organisations

  • Division of Gastroenterology and Hepatology, Graduate school of medical and dental sciences, Niigata University, Chuo-ku, Niigata 951-8510, Japan


The liver has a high regenerative capacity after acute liver injury, but this is often impaired during chronic liver injury. The existence of a dedicated liver stem cell population that acts as a source of regeneration during chronic liver injury has been controversial. Recent advances in transgenic models and cellular reprogramming have provided new insights into the plasticity of the liver epithelium and directions for the development of future therapies. This article will highlight recent findings about the cellular source of regeneration during liver injury and the advances in promoting liver regeneration.


Original languageEnglish
Pages (from-to)1037-1049
Number of pages13
JournalWorld Journal of Gastroenterology
Issue number9
Publication statusPublished - 7 Mar 2019


  • Liver regeneration, Stem cells, Cellular plasticity