Liver sinusoidal endothelial cells - gatekeepers of hepatic immunity

Research output: Contribution to journalReview article

External organisations

  • Centre for Liver Research and NIHR Birmingham Liver Biomedical Research Unit, Institute of Biomedical Research, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.
  • Liver Unit, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
  • Centre for Liver Research and NIHR Birmingham Biomedical Research Centre, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK. d.h.adams@bham.ac.uk.
  • Liver Unit, University Hospitals Birmingham NHS Trust, Birmingham, UK. d.h.adams@bham.ac.uk.

Abstract

Liver sinusoidal endothelial cells (LSECs) line the low shear, sinusoidal capillary channels of the liver and are the most abundant non-parenchymal hepatic cell population. LSECs do not simply form a barrier within the hepatic sinusoids but have vital physiological and immunological functions, including filtration, endocytosis, antigen presentation and leukocyte recruitment. Reflecting these multifunctional properties, LSECs display unique structural and phenotypic features that differentiate them from the capillary endothelium present within other organs. It is now clear that LSECs have a critical role in maintaining immune homeostasis within the liver and in mediating the immune response during acute and chronic liver injury. In this Review, we outline how LSECs influence the immune microenvironment within the liver and discuss their contribution to immune-mediated liver diseases and the complications of fibrosis and carcinogenesis.

Details

Original languageEnglish
JournalNature Reviews. Gastroenterology & Hepatology
Early online date29 May 2018
Publication statusE-pub ahead of print - 29 May 2018

Keywords

  • Journal Article, Review