Abstract
Liposome-entrapped desferrioxamine was administered to iron-over-loaded 59Fe lavelled mice. When given orally or intraperitoneally entrapment did not enhance the effect of the chelator, but given intravenously liposomal desferrioxamine doubled the 59Fe excretion for a given dose of the drug, and excretion after a single dose continued for up to 3 d. In addition, liposomes containing ionophore A23187 administered concurrently with DTPA caused an excretion of 59Fe, whereas DTPA alone had no effect.
| Original language | English |
|---|---|
| Pages (from-to) | 357-63 |
| Number of pages | 7 |
| Journal | British Journal of Haematology |
| Volume | 41 |
| Issue number | 3 |
| Publication status | Published - Mar 1979 |
Keywords
- Pentetic Acid
- Anti-Bacterial Agents
- Animals
- Injections, Intravenous
- Lasalocid
- Iron Chelating Agents
- Mice
- Liposomes
- Iron
- Deferoxamine