Lipid metabolism links nutrient-exercise timing to insulin sensitivity in men classified as overweight or obese

Research output: Contribution to journalArticlepeer-review

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Lipid metabolism links nutrient-exercise timing to insulin sensitivity in men classified as overweight or obese. / Edinburgh, Robert; Bradley, Helen; Abdullah, Nurul; Robinson, Scott; Chrzanowksi-Smith, Oliver; Walhin, Jean-Philippe; Joanisse, Sophie; Manolopoulos, Konstantinos; Philp, Andrew; Hengist, Aaron; Chabowski, Adrian; Brodsky, Frances; Koumanov, Francoise; Betts, James; Thompson, Dylan ; Wallis, Gareth; Gonzalez, Javier T.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 105, No. 3, 03.2020, p. 660–676.

Research output: Contribution to journalArticlepeer-review

Harvard

Edinburgh, R, Bradley, H, Abdullah, N, Robinson, S, Chrzanowksi-Smith, O, Walhin, J-P, Joanisse, S, Manolopoulos, K, Philp, A, Hengist, A, Chabowski, A, Brodsky, F, Koumanov, F, Betts, J, Thompson, D, Wallis, G & Gonzalez, JT 2020, 'Lipid metabolism links nutrient-exercise timing to insulin sensitivity in men classified as overweight or obese', Journal of Clinical Endocrinology and Metabolism, vol. 105, no. 3, pp. 660–676. https://doi.org/10.1210/clinem/dgz104

APA

Edinburgh, R., Bradley, H., Abdullah, N., Robinson, S., Chrzanowksi-Smith, O., Walhin, J-P., Joanisse, S., Manolopoulos, K., Philp, A., Hengist, A., Chabowski, A., Brodsky, F., Koumanov, F., Betts, J., Thompson, D., Wallis, G., & Gonzalez, J. T. (2020). Lipid metabolism links nutrient-exercise timing to insulin sensitivity in men classified as overweight or obese. Journal of Clinical Endocrinology and Metabolism, 105(3), 660–676. https://doi.org/10.1210/clinem/dgz104

Vancouver

Author

Edinburgh, Robert ; Bradley, Helen ; Abdullah, Nurul ; Robinson, Scott ; Chrzanowksi-Smith, Oliver ; Walhin, Jean-Philippe ; Joanisse, Sophie ; Manolopoulos, Konstantinos ; Philp, Andrew ; Hengist, Aaron ; Chabowski, Adrian ; Brodsky, Frances ; Koumanov, Francoise ; Betts, James ; Thompson, Dylan ; Wallis, Gareth ; Gonzalez, Javier T. / Lipid metabolism links nutrient-exercise timing to insulin sensitivity in men classified as overweight or obese. In: Journal of Clinical Endocrinology and Metabolism. 2020 ; Vol. 105, No. 3. pp. 660–676.

Bibtex

@article{cc520cec36f14989a68956cfc89b0968,
title = "Lipid metabolism links nutrient-exercise timing to insulin sensitivity in men classified as overweight or obese",
abstract = "Context: Pre-exercise nutrient availability alters acute metabolic responses to exercise, which could modulate training responsiveness. Objective: To assess acute and chronic effects of exercise performed before versus after nutrient ingestion on whole-body and intramuscular lipid utilization and postprandial glucose metabolism. Design: (1) Acute, randomized, crossover design (Acute Study); (2) 6-week, randomized, controlled design (Training Study). Setting: General community. Participants: Men with overweight/obesity (mean ± standard deviation, body mass index: 30.2 ± 3.5 kg·m -2 for Acute Study, 30.9 ± 4.5 kg·m -2 for Training Study). Interventions: Moderate-intensity cycling performed before versus after mixed-macronutrient breakfast (Acute Study) or carbohydrate (Training Study) ingestion. Results: Acute Study -exercise before versus after breakfast consumption increased net intramuscular lipid utilization in type I (net change: -3.44 ± 2.63% versus 1.44 ± 4.18% area lipid staining, P < 0.01) and type II fibers (-1.89 ± 2.48% versus 1.83 ± 1.92% area lipid staining, P < 0.05). Training Study -postprandial glycemia was not differentially affected by 6 weeks of exercise training performed before versus after carbohydrate intake (P > 0.05). However, postprandial insulinemia was reduced with exercise training performed before but not after carbohydrate ingestion (P = 0.03). This resulted in increased oral glucose insulin sensitivity (25 ± 38 vs -21 ± 32 mL·min -1·m -2; P = 0.01), associated with increased lipid utilization during exercise (r = 0.50, P = 0.02). Regular exercise before nutrient provision also augmented remodeling of skeletal muscle phospholipids and protein content of the glucose transport protein GLUT4 (P < 0.05). Conclusions: Experiments investigating exercise training and metabolic health should consider nutrient-exercise timing, and exercise performed before versus after nutrient intake (ie, in the fasted state) may exert beneficial effects on lipid utilization and reduce postprandial insulinemia. ",
author = "Robert Edinburgh and Helen Bradley and Nurul Abdullah and Scott Robinson and Oliver Chrzanowksi-Smith and Jean-Philippe Walhin and Sophie Joanisse and Konstantinos Manolopoulos and Andrew Philp and Aaron Hengist and Adrian Chabowski and Frances Brodsky and Francoise Koumanov and James Betts and Dylan Thompson and Gareth Wallis and Gonzalez, {Javier T}",
note = "{\textcopyright} Endocrine Society 2019.",
year = "2020",
month = mar,
doi = "10.1210/clinem/dgz104",
language = "English",
volume = "105",
pages = "660–676",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "Endocrine Society",
number = "3",

}

RIS

TY - JOUR

T1 - Lipid metabolism links nutrient-exercise timing to insulin sensitivity in men classified as overweight or obese

AU - Edinburgh, Robert

AU - Bradley, Helen

AU - Abdullah, Nurul

AU - Robinson, Scott

AU - Chrzanowksi-Smith, Oliver

AU - Walhin, Jean-Philippe

AU - Joanisse, Sophie

AU - Manolopoulos, Konstantinos

AU - Philp, Andrew

AU - Hengist, Aaron

AU - Chabowski, Adrian

AU - Brodsky, Frances

AU - Koumanov, Francoise

AU - Betts, James

AU - Thompson, Dylan

AU - Wallis, Gareth

AU - Gonzalez, Javier T

N1 - © Endocrine Society 2019.

PY - 2020/3

Y1 - 2020/3

N2 - Context: Pre-exercise nutrient availability alters acute metabolic responses to exercise, which could modulate training responsiveness. Objective: To assess acute and chronic effects of exercise performed before versus after nutrient ingestion on whole-body and intramuscular lipid utilization and postprandial glucose metabolism. Design: (1) Acute, randomized, crossover design (Acute Study); (2) 6-week, randomized, controlled design (Training Study). Setting: General community. Participants: Men with overweight/obesity (mean ± standard deviation, body mass index: 30.2 ± 3.5 kg·m -2 for Acute Study, 30.9 ± 4.5 kg·m -2 for Training Study). Interventions: Moderate-intensity cycling performed before versus after mixed-macronutrient breakfast (Acute Study) or carbohydrate (Training Study) ingestion. Results: Acute Study -exercise before versus after breakfast consumption increased net intramuscular lipid utilization in type I (net change: -3.44 ± 2.63% versus 1.44 ± 4.18% area lipid staining, P < 0.01) and type II fibers (-1.89 ± 2.48% versus 1.83 ± 1.92% area lipid staining, P < 0.05). Training Study -postprandial glycemia was not differentially affected by 6 weeks of exercise training performed before versus after carbohydrate intake (P > 0.05). However, postprandial insulinemia was reduced with exercise training performed before but not after carbohydrate ingestion (P = 0.03). This resulted in increased oral glucose insulin sensitivity (25 ± 38 vs -21 ± 32 mL·min -1·m -2; P = 0.01), associated with increased lipid utilization during exercise (r = 0.50, P = 0.02). Regular exercise before nutrient provision also augmented remodeling of skeletal muscle phospholipids and protein content of the glucose transport protein GLUT4 (P < 0.05). Conclusions: Experiments investigating exercise training and metabolic health should consider nutrient-exercise timing, and exercise performed before versus after nutrient intake (ie, in the fasted state) may exert beneficial effects on lipid utilization and reduce postprandial insulinemia.

AB - Context: Pre-exercise nutrient availability alters acute metabolic responses to exercise, which could modulate training responsiveness. Objective: To assess acute and chronic effects of exercise performed before versus after nutrient ingestion on whole-body and intramuscular lipid utilization and postprandial glucose metabolism. Design: (1) Acute, randomized, crossover design (Acute Study); (2) 6-week, randomized, controlled design (Training Study). Setting: General community. Participants: Men with overweight/obesity (mean ± standard deviation, body mass index: 30.2 ± 3.5 kg·m -2 for Acute Study, 30.9 ± 4.5 kg·m -2 for Training Study). Interventions: Moderate-intensity cycling performed before versus after mixed-macronutrient breakfast (Acute Study) or carbohydrate (Training Study) ingestion. Results: Acute Study -exercise before versus after breakfast consumption increased net intramuscular lipid utilization in type I (net change: -3.44 ± 2.63% versus 1.44 ± 4.18% area lipid staining, P < 0.01) and type II fibers (-1.89 ± 2.48% versus 1.83 ± 1.92% area lipid staining, P < 0.05). Training Study -postprandial glycemia was not differentially affected by 6 weeks of exercise training performed before versus after carbohydrate intake (P > 0.05). However, postprandial insulinemia was reduced with exercise training performed before but not after carbohydrate ingestion (P = 0.03). This resulted in increased oral glucose insulin sensitivity (25 ± 38 vs -21 ± 32 mL·min -1·m -2; P = 0.01), associated with increased lipid utilization during exercise (r = 0.50, P = 0.02). Regular exercise before nutrient provision also augmented remodeling of skeletal muscle phospholipids and protein content of the glucose transport protein GLUT4 (P < 0.05). Conclusions: Experiments investigating exercise training and metabolic health should consider nutrient-exercise timing, and exercise performed before versus after nutrient intake (ie, in the fasted state) may exert beneficial effects on lipid utilization and reduce postprandial insulinemia.

UR - http://www.scopus.com/inward/record.url?scp=85078815873&partnerID=8YFLogxK

U2 - 10.1210/clinem/dgz104

DO - 10.1210/clinem/dgz104

M3 - Article

C2 - 31628477

VL - 105

SP - 660

EP - 676

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 3

ER -