Lipid metabolism links nutrient-exercise timing to insulin sensitivity in men classified as overweight or obese

Research output: Contribution to journalArticle

Authors

  • Robert Edinburgh
  • Nurul Abdullah
  • Scott Robinson
  • Oliver Chrzanowksi-Smith
  • Jean-Philippe Walhin
  • Sophie Joanisse
  • Aaron Hengist
  • Adrian Chabowski
  • Frances Brodsky
  • Francoise Koumanov
  • James Betts
  • Dylan Thompson
  • Javier T Gonzalez

External organisations

  • University of Bath
  • Medical University of Bialystok, Poland
  • University College London

Abstract

Context
Pre-exercise nutrient availability alters acute metabolic responses to exercise, which could modulate training responsiveness.

Objective
To assess acute and chronic effects of exercise performed before versus after nutrient ingestion on whole-body and intramuscular lipid utilization, and postprandial glucose metabolism.

Design
1) Acute, randomised, crossover design (Acute Study); 2) 6-week, randomised, controlled design (Training Study).

Setting
General community.

Participants
Men with overweight/obesity (mean±SD, BMI: 30.2±3.5 kg.m-2 for Acute Study, 30.9±4.5 kg.m-2 for Training Study).

Interventions
Moderate-intensity cycling performed before versus after mixed-macronutrient breakfast (Acute Study) or carbohydrate (Training Study) ingestion.

Results
Acute Study - exercise before versus after breakfast consumption increased net intramuscular lipid utilization in type I (net change: -3.44±2.63% versus 1.44±4.18% area lipid staining, p < 0.01) and type II fibres (-1.89±2.48% versus 1.83±1.92% area lipid staining, p < 0.05). Training Study - postprandial glycemia was not differentially affected by 6-weeks of exercise training performed before versus after carbohydrate intake (p>0.05). However, postprandial insulinemia was reduced with exercise training performed before, but not after carbohydrate ingestion (p=0.03). This resulted in increased oral glucose insulin sensitivity (25±38 vs -21±32 mL.min-1.m-2; p=0.01), associated with increased lipid utilization during exercise (r=0.50, p=0.02). Regular exercise before nutrient provision also augmented remodelling of skeletal muscle phospholipids and protein content of the glucose transport protein GLUT4 (p<0.05).

Conclusions
Experiments investigating exercise training and metabolic health should consider nutrient-exercise timing, and exercise performed before versus after nutrient intake (i.e., in the fasted state) may exert beneficial effects on lipid utilisation and reduce postprandial insulinemia.

Details

Original languageEnglish
Article numberdgz104
Pages (from-to)1-17
Number of pages17
JournalJournal of Clinical Endocrinology and Metabolism
Volume105
Issue number3
Early online date19 Oct 2019
Publication statusPublished - Mar 2020