βlinc1 encodes a long noncoding RNA that regulates islet β-cell formation and function

Research output: Contribution to journalArticlepeer-review

Authors

Colleges, School and Institutes

External organisations

  • Columbia University
  • Section of Epigenomics and Disease, Department of Medicine, Imperial College London, London W12 0NN, United Kingdom; Genomic Programming of Beta Cells Laboratory, Institut d'Investigacions Biomediques August Pi I Sunyer (IDIBAPS), Barcelona 08036, Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Madrid 28029, Spain. Electronic address: jferrerm@imperial.ac.uk.

Abstract

Pancreatic β cells are responsible for maintaining glucose homeostasis; their absence or malfunction results in diabetes mellitus. Although there is evidence that long noncoding RNAs (lncRNAs) play important roles in development and disease, none have been investigated in vivo in the context of pancreas development. In this study, we demonstrate that βlinc1 (β-cell long intergenic noncoding RNA 1), a conserved lncRNA, is necessary for the specification and function of insulin-producing β cells through the coordinated regulation of a number of islet-specific transcription factors located in the genomic vicinity of βlinc1. Furthermore, deletion of βlinc1 results in defective islet development and disruption of glucose homeostasis in adult mice.

Details

Original languageEnglish
Pages (from-to)502-507
Number of pages6
JournalGenes & Development
Volume30
Issue number5
Publication statusPublished - 1 Mar 2016

Keywords

  • Animals, Cell Line, Endocrine System, Gene Expression Regulation, Developmental, Gene Knockout Techniques, Glucose Intolerance, Humans, Insulin-Secreting Cells, Mice, Mice, Inbred C57BL, RNA, Long Noncoding, Transcription Factors, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't