Light-controlled thrombin catalysis and clot formation using a photoswitchable G-quadruplex DNA aptamer

Research output: Contribution to journalArticle

Authors

Colleges, School and Institutes

Abstract

The reversible photocontrol of an enzyme governing blood coagulation is demonstrated. The thrombin binding aptamer (TBA), was rendered photochromic by modification with two anthracene groups. Light-triggered anthracene photodimerisation distorts its structure, inhibiting binding of the enzyme thrombin, which in turn triggers catalysis and the resulting clotting process.

Details

Original languageEnglish
Pages (from-to)5627-5630
Number of pages4
JournalChemical Communications
Volume55
Issue number39
Early online date16 Apr 2019
Publication statusPublished - 16 Apr 2019