Light-controlled thrombin catalysis and clot formation using a photoswitchable G-quadruplex DNA aptamer

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Colleges, School and Institutes


The reversible photocontrol of an enzyme governing blood coagulation is demonstrated. The thrombin binding aptamer (TBA), was rendered photochromic by modification with two anthracene groups. Light-triggered anthracene photodimerisation distorts its structure, inhibiting binding of the enzyme thrombin, which in turn triggers catalysis and the resulting clotting process.


Original languageEnglish
Pages (from-to)5627-5630
Number of pages4
JournalChemical Communications
Issue number39
Early online date16 Apr 2019
Publication statusPublished - 16 Apr 2019