Light-controlled thrombin catalysis and clot formation using a photoswitchable G-quadruplex DNA aptamer
Research output: Contribution to journal › Article
The reversible photocontrol of an enzyme governing blood coagulation is demonstrated. The thrombin binding aptamer (TBA), was rendered photochromic by modification with two anthracene groups. Light-triggered anthracene photodimerisation distorts its structure, inhibiting binding of the enzyme thrombin, which in turn triggers catalysis and the resulting clotting process.
|Number of pages||4|
|Early online date||16 Apr 2019|
|Publication status||Published - 16 Apr 2019|