Lifetime and baseline alcohol intake and risk of cancer of the upper aero-digestive tract in the European Prospective Investigation into Cancer and Nutrition (EPIC) study

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Lifetime and baseline alcohol intake and risk of cancer of the upper aero-digestive tract in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. / Weikert, C; Dietrich, Thomas; Boeing, H; Bergmann, MM; Boutron-Ruault, MC; Clavel-Chapelon, F; Allen, N; Key, T; Lund, E; Olsen, A; Tjønneland, A; Overvad, K; Rohrmann, S; Linseisen, J; Pischon, T; Trichopoulou, A; Weinehall, L; Johansson, I; Sánchez, MJ; Agudo, A; Barricarte, A; Amiano, P; Chirlaque, MD; Quirós, JR; Wirfalt, E; Peeters, PH; Bueno-de-Mesquita, HB; Vrieling, A; Pala, V; Palli, D; Vineis, P; Tumino, R; Panico, S; Bingham, S; Khaw, KT; Norat, T; Jenab, M; Ferrari, P; Slimani, N; Riboli, E.

In: International Journal of Cancer, Vol. 125, No. 2, 15.07.2009, p. 406-12.

Research output: Contribution to journalArticle

Harvard

Weikert, C, Dietrich, T, Boeing, H, Bergmann, MM, Boutron-Ruault, MC, Clavel-Chapelon, F, Allen, N, Key, T, Lund, E, Olsen, A, Tjønneland, A, Overvad, K, Rohrmann, S, Linseisen, J, Pischon, T, Trichopoulou, A, Weinehall, L, Johansson, I, Sánchez, MJ, Agudo, A, Barricarte, A, Amiano, P, Chirlaque, MD, Quirós, JR, Wirfalt, E, Peeters, PH, Bueno-de-Mesquita, HB, Vrieling, A, Pala, V, Palli, D, Vineis, P, Tumino, R, Panico, S, Bingham, S, Khaw, KT, Norat, T, Jenab, M, Ferrari, P, Slimani, N & Riboli, E 2009, 'Lifetime and baseline alcohol intake and risk of cancer of the upper aero-digestive tract in the European Prospective Investigation into Cancer and Nutrition (EPIC) study', International Journal of Cancer, vol. 125, no. 2, pp. 406-12. https://doi.org/10.1002/ijc.24393

APA

Weikert, C., Dietrich, T., Boeing, H., Bergmann, MM., Boutron-Ruault, MC., Clavel-Chapelon, F., Allen, N., Key, T., Lund, E., Olsen, A., Tjønneland, A., Overvad, K., Rohrmann, S., Linseisen, J., Pischon, T., Trichopoulou, A., Weinehall, L., Johansson, I., Sánchez, MJ., ... Riboli, E. (2009). Lifetime and baseline alcohol intake and risk of cancer of the upper aero-digestive tract in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. International Journal of Cancer, 125(2), 406-12. https://doi.org/10.1002/ijc.24393

Vancouver

Author

Weikert, C ; Dietrich, Thomas ; Boeing, H ; Bergmann, MM ; Boutron-Ruault, MC ; Clavel-Chapelon, F ; Allen, N ; Key, T ; Lund, E ; Olsen, A ; Tjønneland, A ; Overvad, K ; Rohrmann, S ; Linseisen, J ; Pischon, T ; Trichopoulou, A ; Weinehall, L ; Johansson, I ; Sánchez, MJ ; Agudo, A ; Barricarte, A ; Amiano, P ; Chirlaque, MD ; Quirós, JR ; Wirfalt, E ; Peeters, PH ; Bueno-de-Mesquita, HB ; Vrieling, A ; Pala, V ; Palli, D ; Vineis, P ; Tumino, R ; Panico, S ; Bingham, S ; Khaw, KT ; Norat, T ; Jenab, M ; Ferrari, P ; Slimani, N ; Riboli, E. / Lifetime and baseline alcohol intake and risk of cancer of the upper aero-digestive tract in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. In: International Journal of Cancer. 2009 ; Vol. 125, No. 2. pp. 406-12.

Bibtex

@article{9e1dd3e5de1643bb82f6318d3e0152e7,
title = "Lifetime and baseline alcohol intake and risk of cancer of the upper aero-digestive tract in the European Prospective Investigation into Cancer and Nutrition (EPIC) study",
abstract = "Recent alcohol consumption is an established risk factor for squamous cell carcinoma (SCC) of the upper aero-digestive tract. In contrast, the role of lifetime exposure to alcohol with regard to risk of SCC is not well established. Historical data on alcohol use are available in 271,253 participants of the European Prospective Investigation into Cancer and Nutrition (EPIC). During 2,330,381 person years, 392 incident SCC cases (279 men and 113 women) were identified. Cox regression was applied to model sex-specific associations between lifetime alcohol intake and SCC risk adjusting for potential confounders including smoking. Compared to men who drank 0.1-6.0 g/day alcohol at lifetime, the relative risks (RR) for developing SCC were significantly increased for men who drank 30.1-60.0 g/day (RR 1.65, 95% confidence interval:1.00-2.71), 60.1-96.0 g/day (RR 2.20, 95%CI 1.23-3.95), and >96.0 g/day, (RR 4.63, 95% CI 2.52-8.48), and for former drinkers (RR 4.14, 95%CI 2.38-7.19). These risk estimates did not considerably change when baseline alcohol intake was analyzed. Compared to women who drank 0.1-6.0 g/day alcohol intake at lifetime, the RR were significantly increased for women who drank >30 g/d (RR 6.05, 95%CI 2.98-12.3). Applying similar categories, the relative risk for baseline alcohol intake was 3.26 (95%CI 1.82-5.87). We observed a stronger association between alcohol intake at lifetime and risk of SCC in women compared to men (p for interaction = 0.045). The strong dose-response relation for lifetime alcohol use underscores that alcohol is an important risk factor of SCC of the upper aero-digestive tract throughout life.",
keywords = "esophagus, larynx, oral cavity, squamous cell carcinoma, pharynx, epidemiology, cohort study",
author = "C Weikert and Thomas Dietrich and H Boeing and MM Bergmann and MC Boutron-Ruault and F Clavel-Chapelon and N Allen and T Key and E Lund and A Olsen and A Tj{\o}nneland and K Overvad and S Rohrmann and J Linseisen and T Pischon and A Trichopoulou and L Weinehall and I Johansson and MJ S{\'a}nchez and A Agudo and A Barricarte and P Amiano and MD Chirlaque and JR Quir{\'o}s and E Wirfalt and PH Peeters and HB Bueno-de-Mesquita and A Vrieling and V Pala and D Palli and P Vineis and R Tumino and S Panico and S Bingham and KT Khaw and T Norat and M Jenab and P Ferrari and N Slimani and E Riboli",
year = "2009",
month = jul,
day = "15",
doi = "10.1002/ijc.24393",
language = "English",
volume = "125",
pages = "406--12",
journal = "International Journal of Cancer",
issn = "0020-7136",
publisher = "Wiley",
number = "2",

}

RIS

TY - JOUR

T1 - Lifetime and baseline alcohol intake and risk of cancer of the upper aero-digestive tract in the European Prospective Investigation into Cancer and Nutrition (EPIC) study

AU - Weikert, C

AU - Dietrich, Thomas

AU - Boeing, H

AU - Bergmann, MM

AU - Boutron-Ruault, MC

AU - Clavel-Chapelon, F

AU - Allen, N

AU - Key, T

AU - Lund, E

AU - Olsen, A

AU - Tjønneland, A

AU - Overvad, K

AU - Rohrmann, S

AU - Linseisen, J

AU - Pischon, T

AU - Trichopoulou, A

AU - Weinehall, L

AU - Johansson, I

AU - Sánchez, MJ

AU - Agudo, A

AU - Barricarte, A

AU - Amiano, P

AU - Chirlaque, MD

AU - Quirós, JR

AU - Wirfalt, E

AU - Peeters, PH

AU - Bueno-de-Mesquita, HB

AU - Vrieling, A

AU - Pala, V

AU - Palli, D

AU - Vineis, P

AU - Tumino, R

AU - Panico, S

AU - Bingham, S

AU - Khaw, KT

AU - Norat, T

AU - Jenab, M

AU - Ferrari, P

AU - Slimani, N

AU - Riboli, E

PY - 2009/7/15

Y1 - 2009/7/15

N2 - Recent alcohol consumption is an established risk factor for squamous cell carcinoma (SCC) of the upper aero-digestive tract. In contrast, the role of lifetime exposure to alcohol with regard to risk of SCC is not well established. Historical data on alcohol use are available in 271,253 participants of the European Prospective Investigation into Cancer and Nutrition (EPIC). During 2,330,381 person years, 392 incident SCC cases (279 men and 113 women) were identified. Cox regression was applied to model sex-specific associations between lifetime alcohol intake and SCC risk adjusting for potential confounders including smoking. Compared to men who drank 0.1-6.0 g/day alcohol at lifetime, the relative risks (RR) for developing SCC were significantly increased for men who drank 30.1-60.0 g/day (RR 1.65, 95% confidence interval:1.00-2.71), 60.1-96.0 g/day (RR 2.20, 95%CI 1.23-3.95), and >96.0 g/day, (RR 4.63, 95% CI 2.52-8.48), and for former drinkers (RR 4.14, 95%CI 2.38-7.19). These risk estimates did not considerably change when baseline alcohol intake was analyzed. Compared to women who drank 0.1-6.0 g/day alcohol intake at lifetime, the RR were significantly increased for women who drank >30 g/d (RR 6.05, 95%CI 2.98-12.3). Applying similar categories, the relative risk for baseline alcohol intake was 3.26 (95%CI 1.82-5.87). We observed a stronger association between alcohol intake at lifetime and risk of SCC in women compared to men (p for interaction = 0.045). The strong dose-response relation for lifetime alcohol use underscores that alcohol is an important risk factor of SCC of the upper aero-digestive tract throughout life.

AB - Recent alcohol consumption is an established risk factor for squamous cell carcinoma (SCC) of the upper aero-digestive tract. In contrast, the role of lifetime exposure to alcohol with regard to risk of SCC is not well established. Historical data on alcohol use are available in 271,253 participants of the European Prospective Investigation into Cancer and Nutrition (EPIC). During 2,330,381 person years, 392 incident SCC cases (279 men and 113 women) were identified. Cox regression was applied to model sex-specific associations between lifetime alcohol intake and SCC risk adjusting for potential confounders including smoking. Compared to men who drank 0.1-6.0 g/day alcohol at lifetime, the relative risks (RR) for developing SCC were significantly increased for men who drank 30.1-60.0 g/day (RR 1.65, 95% confidence interval:1.00-2.71), 60.1-96.0 g/day (RR 2.20, 95%CI 1.23-3.95), and >96.0 g/day, (RR 4.63, 95% CI 2.52-8.48), and for former drinkers (RR 4.14, 95%CI 2.38-7.19). These risk estimates did not considerably change when baseline alcohol intake was analyzed. Compared to women who drank 0.1-6.0 g/day alcohol intake at lifetime, the RR were significantly increased for women who drank >30 g/d (RR 6.05, 95%CI 2.98-12.3). Applying similar categories, the relative risk for baseline alcohol intake was 3.26 (95%CI 1.82-5.87). We observed a stronger association between alcohol intake at lifetime and risk of SCC in women compared to men (p for interaction = 0.045). The strong dose-response relation for lifetime alcohol use underscores that alcohol is an important risk factor of SCC of the upper aero-digestive tract throughout life.

KW - esophagus

KW - larynx

KW - oral cavity

KW - squamous cell carcinoma

KW - pharynx

KW - epidemiology

KW - cohort study

U2 - 10.1002/ijc.24393

DO - 10.1002/ijc.24393

M3 - Article

C2 - 19378340

VL - 125

SP - 406

EP - 412

JO - International Journal of Cancer

JF - International Journal of Cancer

SN - 0020-7136

IS - 2

ER -