Lifestyle-induced decrease in fat mass improves adiponectin secretion in obese adults

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Lifestyle-induced decrease in fat mass improves adiponectin secretion in obese adults. / Kelly, Karen R; Navaneethan, Sankar D; Solomon, Thomas P J; Haus, Jacob M; Cook, Marc; Barkoukis, Hope; Kirwan, John P.

In: Medicine and Science in Sports and Exercise, Vol. 46, No. 5, 2014, p. 920-6.

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Kelly, Karen R ; Navaneethan, Sankar D ; Solomon, Thomas P J ; Haus, Jacob M ; Cook, Marc ; Barkoukis, Hope ; Kirwan, John P. / Lifestyle-induced decrease in fat mass improves adiponectin secretion in obese adults. In: Medicine and Science in Sports and Exercise. 2014 ; Vol. 46, No. 5. pp. 920-6.

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@article{83503687568e4c539b3a52d26f266190,
title = "Lifestyle-induced decrease in fat mass improves adiponectin secretion in obese adults",
abstract = "PURPOSE: Several studies have identified relationships between weight loss and adipokine levels; however, none have looked at the combined effect of aerobic exercise training with the consumption of a low- or a high-glycemic diet. We examined the effects of 12 wk of aerobic exercise combined with either a low-glycemic index diet (∼40 U) plus exercise (LoGIX) or a high-glycemic index diet (∼80 U) diet plus exercise (HiGIX) on plasma leptin and adiponectin (total and high molecular weight [HMW]) in 27 older obese adults (age = 65 ± 0.5 yr, body mass index = 34.5 ± 0.7 kg·m).METHODS: Insulin sensitivity was calculated from an oral glucose tolerance test. Fasting HMW adiponectin and leptin were quantified from plasma samples obtained before the insulin sensitivity index obtained from the oral glucose tolerance test. Glucose and insulin measures were obtained before and every 30 min during the test. Dual-energy x-ray absorptiometry and computerized tomography were used to determine body composition and to quantify subcutaneous and visceral abdominal adiposity, respectively.RESULTS: Fasting leptin was significantly decreased in both groups (LoGIX: preintervention = 33.8 ± 4.7, postintervention = 19.2 ± 4.5; HiGIX: preintervention = 27.9 ± 4.2, postintervention = 11.9 ± 2.2 ng·mL; P = 0.004), and HMW adiponectin was significantly increased (LoGIX: preintervention = 1606.9 ± 34.6, postintervention = 3502.3 ± 57; HiGIX: preintervention = 3704.8 ± 38.1, postintervention = 4284.3 ± 52.8 pg·mL; P = 0.003) after the 12-wk intervention. Total body fat was reduced after both interventions. Visceral fat mass was inversely correlated with HMW adiponectin, whereas subcutaneous fat correlated with leptin.CONCLUSIONS: The data suggest that exercise training, independent of dietary glycemic index, favorably alters HMW adiponectin and leptin secretion and that a reduction in visceral fat mass is a key factor regulating HMW adiponectin in older obese persons.",
keywords = "Adiponectin, Adiposity, Aged, Diet, Carbohydrate-Restricted, Exercise Therapy, Female, Glycemic Index, Humans, Insulin Resistance, Leptin, Male, Middle Aged, Molecular Weight, Obesity, Weight Loss",
author = "Kelly, {Karen R} and Navaneethan, {Sankar D} and Solomon, {Thomas P J} and Haus, {Jacob M} and Marc Cook and Hope Barkoukis and Kirwan, {John P}",
year = "2014",
doi = "10.1249/MSS.0000000000000200",
language = "English",
volume = "46",
pages = "920--6",
journal = "Medicine and Science in Sports and Exercise",
issn = "0195-9131",
publisher = "American College of Sports Medicine",
number = "5",

}

RIS

TY - JOUR

T1 - Lifestyle-induced decrease in fat mass improves adiponectin secretion in obese adults

AU - Kelly, Karen R

AU - Navaneethan, Sankar D

AU - Solomon, Thomas P J

AU - Haus, Jacob M

AU - Cook, Marc

AU - Barkoukis, Hope

AU - Kirwan, John P

PY - 2014

Y1 - 2014

N2 - PURPOSE: Several studies have identified relationships between weight loss and adipokine levels; however, none have looked at the combined effect of aerobic exercise training with the consumption of a low- or a high-glycemic diet. We examined the effects of 12 wk of aerobic exercise combined with either a low-glycemic index diet (∼40 U) plus exercise (LoGIX) or a high-glycemic index diet (∼80 U) diet plus exercise (HiGIX) on plasma leptin and adiponectin (total and high molecular weight [HMW]) in 27 older obese adults (age = 65 ± 0.5 yr, body mass index = 34.5 ± 0.7 kg·m).METHODS: Insulin sensitivity was calculated from an oral glucose tolerance test. Fasting HMW adiponectin and leptin were quantified from plasma samples obtained before the insulin sensitivity index obtained from the oral glucose tolerance test. Glucose and insulin measures were obtained before and every 30 min during the test. Dual-energy x-ray absorptiometry and computerized tomography were used to determine body composition and to quantify subcutaneous and visceral abdominal adiposity, respectively.RESULTS: Fasting leptin was significantly decreased in both groups (LoGIX: preintervention = 33.8 ± 4.7, postintervention = 19.2 ± 4.5; HiGIX: preintervention = 27.9 ± 4.2, postintervention = 11.9 ± 2.2 ng·mL; P = 0.004), and HMW adiponectin was significantly increased (LoGIX: preintervention = 1606.9 ± 34.6, postintervention = 3502.3 ± 57; HiGIX: preintervention = 3704.8 ± 38.1, postintervention = 4284.3 ± 52.8 pg·mL; P = 0.003) after the 12-wk intervention. Total body fat was reduced after both interventions. Visceral fat mass was inversely correlated with HMW adiponectin, whereas subcutaneous fat correlated with leptin.CONCLUSIONS: The data suggest that exercise training, independent of dietary glycemic index, favorably alters HMW adiponectin and leptin secretion and that a reduction in visceral fat mass is a key factor regulating HMW adiponectin in older obese persons.

AB - PURPOSE: Several studies have identified relationships between weight loss and adipokine levels; however, none have looked at the combined effect of aerobic exercise training with the consumption of a low- or a high-glycemic diet. We examined the effects of 12 wk of aerobic exercise combined with either a low-glycemic index diet (∼40 U) plus exercise (LoGIX) or a high-glycemic index diet (∼80 U) diet plus exercise (HiGIX) on plasma leptin and adiponectin (total and high molecular weight [HMW]) in 27 older obese adults (age = 65 ± 0.5 yr, body mass index = 34.5 ± 0.7 kg·m).METHODS: Insulin sensitivity was calculated from an oral glucose tolerance test. Fasting HMW adiponectin and leptin were quantified from plasma samples obtained before the insulin sensitivity index obtained from the oral glucose tolerance test. Glucose and insulin measures were obtained before and every 30 min during the test. Dual-energy x-ray absorptiometry and computerized tomography were used to determine body composition and to quantify subcutaneous and visceral abdominal adiposity, respectively.RESULTS: Fasting leptin was significantly decreased in both groups (LoGIX: preintervention = 33.8 ± 4.7, postintervention = 19.2 ± 4.5; HiGIX: preintervention = 27.9 ± 4.2, postintervention = 11.9 ± 2.2 ng·mL; P = 0.004), and HMW adiponectin was significantly increased (LoGIX: preintervention = 1606.9 ± 34.6, postintervention = 3502.3 ± 57; HiGIX: preintervention = 3704.8 ± 38.1, postintervention = 4284.3 ± 52.8 pg·mL; P = 0.003) after the 12-wk intervention. Total body fat was reduced after both interventions. Visceral fat mass was inversely correlated with HMW adiponectin, whereas subcutaneous fat correlated with leptin.CONCLUSIONS: The data suggest that exercise training, independent of dietary glycemic index, favorably alters HMW adiponectin and leptin secretion and that a reduction in visceral fat mass is a key factor regulating HMW adiponectin in older obese persons.

KW - Adiponectin

KW - Adiposity

KW - Aged

KW - Diet, Carbohydrate-Restricted

KW - Exercise Therapy

KW - Female

KW - Glycemic Index

KW - Humans

KW - Insulin Resistance

KW - Leptin

KW - Male

KW - Middle Aged

KW - Molecular Weight

KW - Obesity

KW - Weight Loss

U2 - 10.1249/MSS.0000000000000200

DO - 10.1249/MSS.0000000000000200

M3 - Article

C2 - 24614337

VL - 46

SP - 920

EP - 926

JO - Medicine and Science in Sports and Exercise

JF - Medicine and Science in Sports and Exercise

SN - 0195-9131

IS - 5

ER -