Life events, perceived stress, and antibody response to influenza vaccination in young, healthy adults

Victoria Burns; Douglas Carroll; Mark Drayson; M Whitham; Christopher Ring

doi:10.1016/S0022-3999(03)00073-4

Life events, perceived stress, and antibody response to influenza vaccination in young, healthy adults

Victoria Burns, Douglas Carroll, Mark Drayson, M Whitham, Christopher Ring

Research output: Contribution to journal › Article

52 Citations (Scopus)

Abstract

OBJECTIVES: Chronic stress has been associated with impaired response to influenza vaccination in the elderly. This study investigated whether mild, intermittent stress experienced by young, healthy adults has a similar effect. METHODS: Antibody and psychological status were determined prevaccination and 5 weeks and 5 months later; a fourfold increase in antibody to at least one viral strain was considered protective. RESULTS: At 5 months, unprotected participants reported significantly more life events and tended to report more perceived stress than those who were protected. CONCLUSIONS: Psychological stress is detrimental to long-term maintenance of antibody levels following vaccination in young, healthy adults.

Original language	English
Pages (from-to)	569-572
Number of pages	4
Journal	Journal of Psychosomatic Research
Volume	55
Issue number	6
DOIs	https://doi.org/10.1016/S0022-3999(03)00073-4
Publication status	Published - 1 Dec 2003

Keywords

psychosocial stress
psychoneuroimmunology
vaccination

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/S0022-3999(03)00073-4

Cite this

@article{5dc552988d994abdb6020e9c9111db62,

title = "Life events, perceived stress, and antibody response to influenza vaccination in young, healthy adults",

abstract = "OBJECTIVES: Chronic stress has been associated with impaired response to influenza vaccination in the elderly. This study investigated whether mild, intermittent stress experienced by young, healthy adults has a similar effect. METHODS: Antibody and psychological status were determined prevaccination and 5 weeks and 5 months later; a fourfold increase in antibody to at least one viral strain was considered protective. RESULTS: At 5 months, unprotected participants reported significantly more life events and tended to report more perceived stress than those who were protected. CONCLUSIONS: Psychological stress is detrimental to long-term maintenance of antibody levels following vaccination in young, healthy adults.",

keywords = "psychosocial stress, psychoneuroimmunology, vaccination",

author = "Victoria Burns and Douglas Carroll and Mark Drayson and M Whitham and Christopher Ring",

year = "2003",

month = dec,

day = "1",

doi = "10.1016/S0022-3999(03)00073-4",

language = "English",

volume = "55",

pages = "569--572",

journal = "Journal of Psychosomatic Research",

publisher = "Elsevier",

number = "6",

}

TY - JOUR

T1 - Life events, perceived stress, and antibody response to influenza vaccination in young, healthy adults

AU - Burns, Victoria

AU - Carroll, Douglas

AU - Drayson, Mark

AU - Whitham, M

AU - Ring, Christopher

PY - 2003/12/1

Y1 - 2003/12/1

N2 - OBJECTIVES: Chronic stress has been associated with impaired response to influenza vaccination in the elderly. This study investigated whether mild, intermittent stress experienced by young, healthy adults has a similar effect. METHODS: Antibody and psychological status were determined prevaccination and 5 weeks and 5 months later; a fourfold increase in antibody to at least one viral strain was considered protective. RESULTS: At 5 months, unprotected participants reported significantly more life events and tended to report more perceived stress than those who were protected. CONCLUSIONS: Psychological stress is detrimental to long-term maintenance of antibody levels following vaccination in young, healthy adults.

AB - OBJECTIVES: Chronic stress has been associated with impaired response to influenza vaccination in the elderly. This study investigated whether mild, intermittent stress experienced by young, healthy adults has a similar effect. METHODS: Antibody and psychological status were determined prevaccination and 5 weeks and 5 months later; a fourfold increase in antibody to at least one viral strain was considered protective. RESULTS: At 5 months, unprotected participants reported significantly more life events and tended to report more perceived stress than those who were protected. CONCLUSIONS: Psychological stress is detrimental to long-term maintenance of antibody levels following vaccination in young, healthy adults.

KW - psychosocial stress

KW - psychoneuroimmunology

KW - vaccination

UR - http://www.scopus.com/inward/record.url?scp=1042277848&partnerID=8YFLogxK

U2 - 10.1016/S0022-3999(03)00073-4

DO - 10.1016/S0022-3999(03)00073-4

M3 - Article

C2 - 14642989

VL - 55

SP - 569

EP - 572

JO - Journal of Psychosomatic Research

JF - Journal of Psychosomatic Research

IS - 6

ER -

Life events, perceived stress, and antibody response to influenza vaccination in young, healthy adults

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this