Life events, perceived stress, and antibody response to influenza vaccination in young, healthy adults
Research output: Contribution to journal › Article
Colleges, School and Institutes
OBJECTIVES: Chronic stress has been associated with impaired response to influenza vaccination in the elderly. This study investigated whether mild, intermittent stress experienced by young, healthy adults has a similar effect. METHODS: Antibody and psychological status were determined prevaccination and 5 weeks and 5 months later; a fourfold increase in antibody to at least one viral strain was considered protective. RESULTS: At 5 months, unprotected participants reported significantly more life events and tended to report more perceived stress than those who were protected. CONCLUSIONS: Psychological stress is detrimental to long-term maintenance of antibody levels following vaccination in young, healthy adults.
|Number of pages||4|
|Journal||Journal of Psychosomatic Research|
|Publication status||Published - 1 Dec 2003|
- psychosocial stress, psychoneuroimmunology, vaccination