Life events, perceived stress, and antibody response to influenza vaccination in young, healthy adults
Research output: Contribution to journal › Article
Authors
Colleges, School and Institutes
Abstract
OBJECTIVES: Chronic stress has been associated with impaired response to influenza vaccination in the elderly. This study investigated whether mild, intermittent stress experienced by young, healthy adults has a similar effect. METHODS: Antibody and psychological status were determined prevaccination and 5 weeks and 5 months later; a fourfold increase in antibody to at least one viral strain was considered protective. RESULTS: At 5 months, unprotected participants reported significantly more life events and tended to report more perceived stress than those who were protected. CONCLUSIONS: Psychological stress is detrimental to long-term maintenance of antibody levels following vaccination in young, healthy adults.
Details
Original language | English |
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Pages (from-to) | 569-572 |
Number of pages | 4 |
Journal | Journal of Psychosomatic Research |
Volume | 55 |
Issue number | 6 |
Publication status | Published - 1 Dec 2003 |
Keywords
- psychosocial stress, psychoneuroimmunology, vaccination