Length-dependent retention of carbon nanotubes in the pleural space of mice initiates sustained inflammation and progressive fibrosis on the parietal pleura

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Length-dependent retention of carbon nanotubes in the pleural space of mice initiates sustained inflammation and progressive fibrosis on the parietal pleura. / Murphy, Fiona A; Poland, Craig A; Duffin, Rodger; Al-Jamal, Khuloud T; Ali-Boucetta, Hanene; Nunes, Antonio; Byrne, Fiona; Prina-Mello, Adriele; Volkov, Yuri; Li, Shouping; Mather, Stephen J; Bianco, Alberto; Prato, Maurizio; Macnee, William; Wallace, William A; Kostarelos, Kostas; Donaldson, Ken.

In: The American Journal of Pathology, Vol. 178, No. 6, 06.2011, p. 2587-600.

Research output: Contribution to journalArticlepeer-review

Harvard

Murphy, FA, Poland, CA, Duffin, R, Al-Jamal, KT, Ali-Boucetta, H, Nunes, A, Byrne, F, Prina-Mello, A, Volkov, Y, Li, S, Mather, SJ, Bianco, A, Prato, M, Macnee, W, Wallace, WA, Kostarelos, K & Donaldson, K 2011, 'Length-dependent retention of carbon nanotubes in the pleural space of mice initiates sustained inflammation and progressive fibrosis on the parietal pleura', The American Journal of Pathology, vol. 178, no. 6, pp. 2587-600. https://doi.org/10.1016/j.ajpath.2011.02.040

APA

Murphy, F. A., Poland, C. A., Duffin, R., Al-Jamal, K. T., Ali-Boucetta, H., Nunes, A., Byrne, F., Prina-Mello, A., Volkov, Y., Li, S., Mather, S. J., Bianco, A., Prato, M., Macnee, W., Wallace, W. A., Kostarelos, K., & Donaldson, K. (2011). Length-dependent retention of carbon nanotubes in the pleural space of mice initiates sustained inflammation and progressive fibrosis on the parietal pleura. The American Journal of Pathology, 178(6), 2587-600. https://doi.org/10.1016/j.ajpath.2011.02.040

Vancouver

Author

Murphy, Fiona A ; Poland, Craig A ; Duffin, Rodger ; Al-Jamal, Khuloud T ; Ali-Boucetta, Hanene ; Nunes, Antonio ; Byrne, Fiona ; Prina-Mello, Adriele ; Volkov, Yuri ; Li, Shouping ; Mather, Stephen J ; Bianco, Alberto ; Prato, Maurizio ; Macnee, William ; Wallace, William A ; Kostarelos, Kostas ; Donaldson, Ken. / Length-dependent retention of carbon nanotubes in the pleural space of mice initiates sustained inflammation and progressive fibrosis on the parietal pleura. In: The American Journal of Pathology. 2011 ; Vol. 178, No. 6. pp. 2587-600.

Bibtex

@article{543c6bed3a0444d18667c5a41640bfbc,
title = "Length-dependent retention of carbon nanotubes in the pleural space of mice initiates sustained inflammation and progressive fibrosis on the parietal pleura",
abstract = "The fibrous shape of carbon nanotubes (CNTs) raises concern that they may pose an asbestos-like inhalation hazard, leading to the development of diseases, especially mesothelioma. Direct instillation of long and short CNTs into the pleural cavity, the site of mesothelioma development, produced asbestos-like length-dependent responses. The response to long CNTs and long asbestos was characterized by acute inflammation, leading to progressive fibrosis on the parietal pleura, where stomata of strictly defined size limit the egress of long, but not short, fibers. This was confirmed by demonstrating clearance of short, but not long, CNT and nickel nanowires and by visualizing the migration of short CNTs from the pleural space by single-photon emission computed tomographic imaging. Our data confirm the hypothesis that, although a proportion of all deposited particles passes through the pleura, the pathogenicity of long CNTs and other fibers arises as a result of length-dependent retention at the stomata on the parietal pleura.",
keywords = "Animals, Cell Proliferation, Disease Progression, Epithelium/pathology, Fibrosis, Inflammation/complications, Lymph Nodes/pathology, Mediastinum/pathology, Mice, Nanotubes, Carbon/chemistry, Nanowires/ultrastructure, Particle Size, Pleura/pathology, Pleural Cavity/pathology, Time Factors, Tomography, Emission-Computed, Single-Photon, Tomography, X-Ray Computed",
author = "Murphy, {Fiona A} and Poland, {Craig A} and Rodger Duffin and Al-Jamal, {Khuloud T} and Hanene Ali-Boucetta and Antonio Nunes and Fiona Byrne and Adriele Prina-Mello and Yuri Volkov and Shouping Li and Mather, {Stephen J} and Alberto Bianco and Maurizio Prato and William Macnee and Wallace, {William A} and Kostas Kostarelos and Ken Donaldson",
note = "Copyright {\textcopyright} 2011 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.",
year = "2011",
month = jun,
doi = "10.1016/j.ajpath.2011.02.040",
language = "English",
volume = "178",
pages = "2587--600",
journal = "The American Journal of Pathology",
issn = "0002-9440",
publisher = "American Society for Investigative Pathology",
number = "6",

}

RIS

TY - JOUR

T1 - Length-dependent retention of carbon nanotubes in the pleural space of mice initiates sustained inflammation and progressive fibrosis on the parietal pleura

AU - Murphy, Fiona A

AU - Poland, Craig A

AU - Duffin, Rodger

AU - Al-Jamal, Khuloud T

AU - Ali-Boucetta, Hanene

AU - Nunes, Antonio

AU - Byrne, Fiona

AU - Prina-Mello, Adriele

AU - Volkov, Yuri

AU - Li, Shouping

AU - Mather, Stephen J

AU - Bianco, Alberto

AU - Prato, Maurizio

AU - Macnee, William

AU - Wallace, William A

AU - Kostarelos, Kostas

AU - Donaldson, Ken

N1 - Copyright © 2011 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

PY - 2011/6

Y1 - 2011/6

N2 - The fibrous shape of carbon nanotubes (CNTs) raises concern that they may pose an asbestos-like inhalation hazard, leading to the development of diseases, especially mesothelioma. Direct instillation of long and short CNTs into the pleural cavity, the site of mesothelioma development, produced asbestos-like length-dependent responses. The response to long CNTs and long asbestos was characterized by acute inflammation, leading to progressive fibrosis on the parietal pleura, where stomata of strictly defined size limit the egress of long, but not short, fibers. This was confirmed by demonstrating clearance of short, but not long, CNT and nickel nanowires and by visualizing the migration of short CNTs from the pleural space by single-photon emission computed tomographic imaging. Our data confirm the hypothesis that, although a proportion of all deposited particles passes through the pleura, the pathogenicity of long CNTs and other fibers arises as a result of length-dependent retention at the stomata on the parietal pleura.

AB - The fibrous shape of carbon nanotubes (CNTs) raises concern that they may pose an asbestos-like inhalation hazard, leading to the development of diseases, especially mesothelioma. Direct instillation of long and short CNTs into the pleural cavity, the site of mesothelioma development, produced asbestos-like length-dependent responses. The response to long CNTs and long asbestos was characterized by acute inflammation, leading to progressive fibrosis on the parietal pleura, where stomata of strictly defined size limit the egress of long, but not short, fibers. This was confirmed by demonstrating clearance of short, but not long, CNT and nickel nanowires and by visualizing the migration of short CNTs from the pleural space by single-photon emission computed tomographic imaging. Our data confirm the hypothesis that, although a proportion of all deposited particles passes through the pleura, the pathogenicity of long CNTs and other fibers arises as a result of length-dependent retention at the stomata on the parietal pleura.

KW - Animals

KW - Cell Proliferation

KW - Disease Progression

KW - Epithelium/pathology

KW - Fibrosis

KW - Inflammation/complications

KW - Lymph Nodes/pathology

KW - Mediastinum/pathology

KW - Mice

KW - Nanotubes, Carbon/chemistry

KW - Nanowires/ultrastructure

KW - Particle Size

KW - Pleura/pathology

KW - Pleural Cavity/pathology

KW - Time Factors

KW - Tomography, Emission-Computed, Single-Photon

KW - Tomography, X-Ray Computed

U2 - 10.1016/j.ajpath.2011.02.040

DO - 10.1016/j.ajpath.2011.02.040

M3 - Article

C2 - 21641383

VL - 178

SP - 2587

EP - 2600

JO - The American Journal of Pathology

JF - The American Journal of Pathology

SN - 0002-9440

IS - 6

ER -