Left ventricular pacing improves haemodynamic variables in patients with heart failure with a normal QRS duration

Research output: Contribution to journalArticle

Standard

Left ventricular pacing improves haemodynamic variables in patients with heart failure with a normal QRS duration. / Turner, MS; Bleasdale, RA; Mumford, CE; Frenneaux, Michael; Morris-Thurgood, JA.

In: Heart, Vol. 90, 01.01.2004, p. 502-505.

Research output: Contribution to journalArticle

Harvard

APA

Vancouver

Author

Turner, MS ; Bleasdale, RA ; Mumford, CE ; Frenneaux, Michael ; Morris-Thurgood, JA. / Left ventricular pacing improves haemodynamic variables in patients with heart failure with a normal QRS duration. In: Heart. 2004 ; Vol. 90. pp. 502-505.

Bibtex

@article{4bccb829ae84484fa0055cb62ded6fcb,
title = "Left ventricular pacing improves haemodynamic variables in patients with heart failure with a normal QRS duration",
abstract = "OBJECTIVES: To assess whether patients with congestive heart failure (CHF) and a normal QRS duration can benefit from left ventricular (VDD-LV) pacing. DESIGN: Cardiac resynchronisation is reserved for patients with a broad QRS duration on the premise that systolic resynchronisation is the mechanism of benefit, yet improvement from pacing correlates poorly with QRS duration. In CHF patients with a broad QRS duration, those with a high resting pulmonary capillary wedge pressure (PCWP) > 15 mm Hg benefit. In this acute haemodynamic VDD-LV pacing study, patients with CHF with a normal QRS duration were divided into two groups--patients with a resting PCWP > 15 mm Hg and patients with a resting PCWP <15 mm Hg--to determine whether benefit is predicted by a high resting PCWP. PATIENTS: 20 patients with CHF, New York Heart Association functional class IIb-IV, all with a normal QRS duration ( 15 mm Hg (n = 10), cardiac output increased from 3.9 (1.5) to 4.5 (1.65) l/min (p <0.01), despite a fall in PCWP from 24.7 (7.1) to 21.0 (6.2) mm Hg (p <0.001). In patients with a PCWP <15 mm Hg there was no change in PCWP or cardiac output. Combined data showed that PCWP decreased from 17.0 (9.1) to 15.3 (7.7) mm Hg during VDD-LV pacing (p <0.014) and cardiac output increased non-significantly from 4.7 (1.5) to 4.9 (1.5) (p = 0.125). CONCLUSIONS: Patients with CHF with a normal QRS duration and PCWP > 15 mm Hg derive acute haemodynamic benefit from VDD-LV pacing.",
author = "MS Turner and RA Bleasdale and CE Mumford and Michael Frenneaux and JA Morris-Thurgood",
year = "2004",
month = jan,
day = "1",
doi = "10.1136/hrt.2003.011759",
language = "English",
volume = "90",
pages = "502--505",
journal = "Heart",
issn = "1355-6037",
publisher = "BMJ Publishing Group",

}

RIS

TY - JOUR

T1 - Left ventricular pacing improves haemodynamic variables in patients with heart failure with a normal QRS duration

AU - Turner, MS

AU - Bleasdale, RA

AU - Mumford, CE

AU - Frenneaux, Michael

AU - Morris-Thurgood, JA

PY - 2004/1/1

Y1 - 2004/1/1

N2 - OBJECTIVES: To assess whether patients with congestive heart failure (CHF) and a normal QRS duration can benefit from left ventricular (VDD-LV) pacing. DESIGN: Cardiac resynchronisation is reserved for patients with a broad QRS duration on the premise that systolic resynchronisation is the mechanism of benefit, yet improvement from pacing correlates poorly with QRS duration. In CHF patients with a broad QRS duration, those with a high resting pulmonary capillary wedge pressure (PCWP) > 15 mm Hg benefit. In this acute haemodynamic VDD-LV pacing study, patients with CHF with a normal QRS duration were divided into two groups--patients with a resting PCWP > 15 mm Hg and patients with a resting PCWP <15 mm Hg--to determine whether benefit is predicted by a high resting PCWP. PATIENTS: 20 patients with CHF, New York Heart Association functional class IIb-IV, all with a normal QRS duration ( 15 mm Hg (n = 10), cardiac output increased from 3.9 (1.5) to 4.5 (1.65) l/min (p <0.01), despite a fall in PCWP from 24.7 (7.1) to 21.0 (6.2) mm Hg (p <0.001). In patients with a PCWP <15 mm Hg there was no change in PCWP or cardiac output. Combined data showed that PCWP decreased from 17.0 (9.1) to 15.3 (7.7) mm Hg during VDD-LV pacing (p <0.014) and cardiac output increased non-significantly from 4.7 (1.5) to 4.9 (1.5) (p = 0.125). CONCLUSIONS: Patients with CHF with a normal QRS duration and PCWP > 15 mm Hg derive acute haemodynamic benefit from VDD-LV pacing.

AB - OBJECTIVES: To assess whether patients with congestive heart failure (CHF) and a normal QRS duration can benefit from left ventricular (VDD-LV) pacing. DESIGN: Cardiac resynchronisation is reserved for patients with a broad QRS duration on the premise that systolic resynchronisation is the mechanism of benefit, yet improvement from pacing correlates poorly with QRS duration. In CHF patients with a broad QRS duration, those with a high resting pulmonary capillary wedge pressure (PCWP) > 15 mm Hg benefit. In this acute haemodynamic VDD-LV pacing study, patients with CHF with a normal QRS duration were divided into two groups--patients with a resting PCWP > 15 mm Hg and patients with a resting PCWP <15 mm Hg--to determine whether benefit is predicted by a high resting PCWP. PATIENTS: 20 patients with CHF, New York Heart Association functional class IIb-IV, all with a normal QRS duration ( 15 mm Hg (n = 10), cardiac output increased from 3.9 (1.5) to 4.5 (1.65) l/min (p <0.01), despite a fall in PCWP from 24.7 (7.1) to 21.0 (6.2) mm Hg (p <0.001). In patients with a PCWP <15 mm Hg there was no change in PCWP or cardiac output. Combined data showed that PCWP decreased from 17.0 (9.1) to 15.3 (7.7) mm Hg during VDD-LV pacing (p <0.014) and cardiac output increased non-significantly from 4.7 (1.5) to 4.9 (1.5) (p = 0.125). CONCLUSIONS: Patients with CHF with a normal QRS duration and PCWP > 15 mm Hg derive acute haemodynamic benefit from VDD-LV pacing.

UR - http://www.scopus.com/inward/record.url?scp=1942468097&partnerID=8YFLogxK

U2 - 10.1136/hrt.2003.011759

DO - 10.1136/hrt.2003.011759

M3 - Article

C2 - 15084543

VL - 90

SP - 502

EP - 505

JO - Heart

JF - Heart

SN - 1355-6037

ER -