Lee Silverman Voice Treatment versus standard speech and language therapy versus control in Parkinson’s disease: a pilot randomised controlled trial (PD COMM pilot)

Research output: Contribution to journalArticle

Authors

External organisations

  • King's College London
  • Division of Psychology and Language Science, Faculty of Brain Sciences, University College London
  • Glasgow Caledonian University
  • Parkinson’s UK West Midlands Regional Branch
  • Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
  • University of East Anglia
  • University of Nottingham

Abstract

Background: Speech-related problems are common in Parkinson’s disease (PD), but there is little evidence for the effectiveness of standard speech and language therapy (SLT) or Lee Silverman Voice Treatment (LSVTLSVT LOUD®).

Methods: The PD COMM pilot was a three-arm, assessor-blinded, randomised, controlled trial (RCT) ofcomparing LSVTLSVT LOUD®, SLT andversus no intervention (1:1:1 ratio) to assess the feasibility and to inform the design of a full-scale RCT. Non-demented patients with idiopathic PD and speech problems and no SLT for speech problems in the past 2 years were eligible. LSVTLSVT LOUD® is a standardised regime (16 sessions over 4 weeks). SLT comprised individualised content per local practice (typically weekly sessions for 6-8 weeks). Outcomes included recruitment and retention, treatment adherence and data completeness. Outcome data assessedcollected at baseline, 3, 6, and 12 months included patient-reported voice and quality of life measures, resource use, and assessor-rated speech recordings.

Results: Eighty-nine patients were randomised with 90% in the therapy armgroups and 100% in the control grouparm completing the trial. The response rate for Voice Handicap Index (VHI) in each arm was ≥90% at all time-points. VHI was highly correlated with the other speech-related outcome measures. There was a trend to improvement in VHI with LSVTLSVT LOUD® (difference at 3 months compared with control: -12.5 points; 95%CI -26.2, 1.2) and SLT (difference at 3 months compared with control: -9.8 points; 95%CI -23.2, 3.7) which needs to be confirmed in an adequately powered trial.

Conclusion: Randomisation to a three-arm trial of speech therapy including a no intervention control is feasible and acceptable. Compliance with both interventions was good. VHI and other patient-reported outcomes were relevant measures and provided data to inform the sample size for a substantive trial.

Trial registration: International Standard Randomised Controlled Trial Number Register: ISRCTN75223808 registered 22 March 2012

Key Words: Parkinson's disease; pilot randomised controlled trial; speech and language therapy

Details

Original languageEnglish
JournalPilot and Feasibility Studies
Volume4
Issue number30
Publication statusPublished - 10 Jan 2018

Keywords

  • Parkinson's disease, pilot randomised controlled trial, Speech and language therapy