Laser-inscribed contact lens sensors for the detection of analytes in the tear fluid

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Laser-inscribed contact lens sensors for the detection of analytes in the tear fluid. / Moreddu, Rosalia; Wolffsohn, James S.; Vigolo, Daniele; Yetisen, Ali K.

In: Sensors and Actuators B: Chemical, Vol. 317, 128183, 15.08.2020.

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@article{d5796e3da34b488b88a549a6004c988f,
title = "Laser-inscribed contact lens sensors for the detection of analytes in the tear fluid",
abstract = "Tears exhibit compositional variations as a response to ocular and systemic metabolic conditions, and they can therefore be used for the assessment of physiological health. Here, microfluidic contact lenses were developed as wearable platforms for in situ tear pH, glucose, protein, and nitrite ions sensing. The microfluidic system was inscribed in commercial contact lenses by CO2 laser ablation. The microchannel consisted on a central ring with four branches, and biosensors were embedded within microcavities located at the branches ends. The device was tested with artificial tears and colorimetric readouts were performed using a smartphone-MATLAB algorithm based on the nearest neighbor model. Sensors responded within a time range of 15 s, and yielded sensitivities of 12.23 nm/pH unit, 1.4 nm/mmol L−1 of glucose, 0.49 nm/g L−1 of proteins, and 0.03 nm/μmol L−1 of nitrites. Contact lens sensing platforms may provide on-eye tears screening with applications in the monitoring of the ocular health both in clinics and at point-of-care settings.",
keywords = "contact lenses, boimarkers, tear fluid, biosensors, point-of-care diagnostics",
author = "Rosalia Moreddu and Wolffsohn, {James S.} and Daniele Vigolo and Yetisen, {Ali K.}",
year = "2020",
month = aug,
day = "15",
doi = "10.1016/j.snb.2020.128183",
language = "English",
volume = "317",
journal = "Sensors and Actuators B: Chemical",
issn = "0925-4005",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Laser-inscribed contact lens sensors for the detection of analytes in the tear fluid

AU - Moreddu, Rosalia

AU - Wolffsohn, James S.

AU - Vigolo, Daniele

AU - Yetisen, Ali K.

PY - 2020/8/15

Y1 - 2020/8/15

N2 - Tears exhibit compositional variations as a response to ocular and systemic metabolic conditions, and they can therefore be used for the assessment of physiological health. Here, microfluidic contact lenses were developed as wearable platforms for in situ tear pH, glucose, protein, and nitrite ions sensing. The microfluidic system was inscribed in commercial contact lenses by CO2 laser ablation. The microchannel consisted on a central ring with four branches, and biosensors were embedded within microcavities located at the branches ends. The device was tested with artificial tears and colorimetric readouts were performed using a smartphone-MATLAB algorithm based on the nearest neighbor model. Sensors responded within a time range of 15 s, and yielded sensitivities of 12.23 nm/pH unit, 1.4 nm/mmol L−1 of glucose, 0.49 nm/g L−1 of proteins, and 0.03 nm/μmol L−1 of nitrites. Contact lens sensing platforms may provide on-eye tears screening with applications in the monitoring of the ocular health both in clinics and at point-of-care settings.

AB - Tears exhibit compositional variations as a response to ocular and systemic metabolic conditions, and they can therefore be used for the assessment of physiological health. Here, microfluidic contact lenses were developed as wearable platforms for in situ tear pH, glucose, protein, and nitrite ions sensing. The microfluidic system was inscribed in commercial contact lenses by CO2 laser ablation. The microchannel consisted on a central ring with four branches, and biosensors were embedded within microcavities located at the branches ends. The device was tested with artificial tears and colorimetric readouts were performed using a smartphone-MATLAB algorithm based on the nearest neighbor model. Sensors responded within a time range of 15 s, and yielded sensitivities of 12.23 nm/pH unit, 1.4 nm/mmol L−1 of glucose, 0.49 nm/g L−1 of proteins, and 0.03 nm/μmol L−1 of nitrites. Contact lens sensing platforms may provide on-eye tears screening with applications in the monitoring of the ocular health both in clinics and at point-of-care settings.

KW - contact lenses

KW - boimarkers

KW - tear fluid

KW - biosensors

KW - point-of-care diagnostics

UR - http://www.scopus.com/inward/record.url?scp=85085072117&partnerID=8YFLogxK

U2 - 10.1016/j.snb.2020.128183

DO - 10.1016/j.snb.2020.128183

M3 - Article

VL - 317

JO - Sensors and Actuators B: Chemical

JF - Sensors and Actuators B: Chemical

SN - 0925-4005

M1 - 128183

ER -