Large-scale replication and heterogeneity in Parkinson disease genetic loci

Manu Sharma; John P A Ioannidis; Jan O Aasly; Grazia Annesi; Alexis Brice; Christine Van Broeckhoven; Lars Bertram; Maria Bozi; David Crosiers; Carl Clarke; Maurizio Facheris; Matthew Farrer; Gaetan Garraux; Suzana Gispert; Georg Auburger; Carles Vilariño-Güell; Georgios M Hadjigeorgiou; Andrew A Hicks; Nobutaka Hattori; Beom Jeon; Suzanne Lesage; Christina M Lill; Juei-Jueng Lin; Timothy Lynch; Peter Lichtner; Anthony E Lang; Vincent Mok; Barbara Jasinska-Myga; George D Mellick; Karen E Morrison; Grzegorz Opala; Peter P Pramstaller; Irene Pichler; Sung Sup Park; Aldo Quattrone; Ekaterina Rogaeva; Owen A Ross; Leonidas Stefanis; Joanne D Stockton; Wataru Satake; Peter A Silburn; Jessie Theuns; Eng-King Tan; Tatsushi Toda; Hiroyuki Tomiyama; Ryan J Uitti; Karin Wirdefeldt; Zbigniew Wszolek; Georgia Xiromerisiou; Kuo-Chu Yueh; Genetic Epidemiology Of Parkinson's Disease (GEO-PD) Consortium

doi:10.1212/WNL.0b013e318264e353

Large-scale replication and heterogeneity in Parkinson disease genetic loci

Manu Sharma, John P A Ioannidis, Jan O Aasly, Grazia Annesi, Alexis Brice, Christine Van Broeckhoven, Lars Bertram, Maria Bozi, David Crosiers, Carl Clarke, Maurizio Facheris, Matthew Farrer, Gaetan Garraux, Suzana Gispert, Georg Auburger, Carles Vilariño-Güell, Georgios M Hadjigeorgiou, Andrew A Hicks, Nobutaka Hattori, Beom JeonSuzanne Lesage, Christina M Lill, Juei-Jueng Lin, Timothy Lynch, Peter Lichtner, Anthony E Lang, Vincent Mok, Barbara Jasinska-Myga, George D Mellick, Karen E Morrison, Grzegorz Opala, Peter P Pramstaller, Irene Pichler, Sung Sup Park, Aldo Quattrone, Ekaterina Rogaeva, Owen A Ross, Leonidas Stefanis, Joanne D Stockton, Wataru Satake, Peter A Silburn, Jessie Theuns, Eng-King Tan, Tatsushi Toda, Hiroyuki Tomiyama, Ryan J Uitti, Karin Wirdefeldt, Zbigniew Wszolek, Georgia Xiromerisiou, Kuo-Chu Yueh, Genetic Epidemiology Of Parkinson's Disease (GEO-PD) Consortium

Physics and Astronomy

Research output: Contribution to journal › Article › peer-review

101 Citations (Scopus)

Abstract

Eleven genetic loci have reached genome-wide significance in a recent meta-analysis of genome-wide association studies in Parkinson disease (PD) based on populations of Caucasian descent. The extent to which these genetic effects are consistent across different populations is unknown.

Original language	English
Pages (from-to)	659-67
Number of pages	9
Journal	Neurology
Volume	79
Issue number	7
DOIs	https://doi.org/10.1212/WNL.0b013e318264e353
Publication status	Published - 14 Aug 2012

Keywords

Aged
Alleles
Case-Control Studies
Female
Gene Frequency
Genetic Loci
Genetic Predisposition to Disease
Genome-Wide Association Study
Genotype
Humans
Male
Middle Aged
Parkinson Disease
Polymorphism, Single Nucleotide

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Sharma, M., Ioannidis, J. P. A., Aasly, J. O., Annesi, G., Brice, A., Van Broeckhoven, C., Bertram, L., Bozi, M., Crosiers, D., Clarke, C., Facheris, M., Farrer, M., Garraux, G., Gispert, S., Auburger, G., Vilariño-Güell, C., Hadjigeorgiou, G. M., Hicks, A. A., Hattori, N., ... Genetic Epidemiology Of Parkinson's Disease (GEO-PD) Consortium (2012). Large-scale replication and heterogeneity in Parkinson disease genetic loci. Neurology, 79(7), 659-67. https://doi.org/10.1212/WNL.0b013e318264e353

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title = "Large-scale replication and heterogeneity in Parkinson disease genetic loci",

abstract = "Eleven genetic loci have reached genome-wide significance in a recent meta-analysis of genome-wide association studies in Parkinson disease (PD) based on populations of Caucasian descent. The extent to which these genetic effects are consistent across different populations is unknown.",

keywords = "Aged, Alleles, Case-Control Studies, Female, Gene Frequency, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Humans, Male, Middle Aged, Parkinson Disease, Polymorphism, Single Nucleotide",

author = "Manu Sharma and Ioannidis, {John P A} and Aasly, {Jan O} and Grazia Annesi and Alexis Brice and {Van Broeckhoven}, Christine and Lars Bertram and Maria Bozi and David Crosiers and Carl Clarke and Maurizio Facheris and Matthew Farrer and Gaetan Garraux and Suzana Gispert and Georg Auburger and Carles Vilari{\~n}o-G{\"u}ell and Hadjigeorgiou, {Georgios M} and Hicks, {Andrew A} and Nobutaka Hattori and Beom Jeon and Suzanne Lesage and Lill, {Christina M} and Juei-Jueng Lin and Timothy Lynch and Peter Lichtner and Lang, {Anthony E} and Vincent Mok and Barbara Jasinska-Myga and Mellick, {George D} and Morrison, {Karen E} and Grzegorz Opala and Pramstaller, {Peter P} and Irene Pichler and Park, {Sung Sup} and Aldo Quattrone and Ekaterina Rogaeva and Ross, {Owen A} and Leonidas Stefanis and Stockton, {Joanne D} and Wataru Satake and Silburn, {Peter A} and Jessie Theuns and Eng-King Tan and Tatsushi Toda and Hiroyuki Tomiyama and Uitti, {Ryan J} and Karin Wirdefeldt and Zbigniew Wszolek and Georgia Xiromerisiou and Kuo-Chu Yueh and {Genetic Epidemiology Of Parkinson's Disease (GEO-PD) Consortium}",

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Sharma, M, Ioannidis, JPA, Aasly, JO, Annesi, G, Brice, A, Van Broeckhoven, C, Bertram, L, Bozi, M, Crosiers, D, Clarke, C, Facheris, M, Farrer, M, Garraux, G, Gispert, S, Auburger, G, Vilariño-Güell, C, Hadjigeorgiou, GM, Hicks, AA, Hattori, N, Jeon, B, Lesage, S, Lill, CM, Lin, J-J, Lynch, T, Lichtner, P, Lang, AE, Mok, V, Jasinska-Myga, B, Mellick, GD, Morrison, KE, Opala, G, Pramstaller, PP, Pichler, I, Park, SS, Quattrone, A, Rogaeva, E, Ross, OA, Stefanis, L, Stockton, JD, Satake, W, Silburn, PA, Theuns, J, Tan, E-K, Toda, T, Tomiyama, H, Uitti, RJ, Wirdefeldt, K, Wszolek, Z, Xiromerisiou, G, Yueh, K-C & Genetic Epidemiology Of Parkinson's Disease (GEO-PD) Consortium 2012, 'Large-scale replication and heterogeneity in Parkinson disease genetic loci', Neurology, vol. 79, no. 7, pp. 659-67. https://doi.org/10.1212/WNL.0b013e318264e353

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AU - Sharma, Manu

AU - Ioannidis, John P A

AU - Aasly, Jan O

AU - Annesi, Grazia

AU - Brice, Alexis

AU - Van Broeckhoven, Christine

AU - Bertram, Lars

AU - Bozi, Maria

AU - Crosiers, David

AU - Clarke, Carl

AU - Facheris, Maurizio

AU - Farrer, Matthew

AU - Garraux, Gaetan

AU - Gispert, Suzana

AU - Auburger, Georg

AU - Vilariño-Güell, Carles

AU - Hadjigeorgiou, Georgios M

AU - Hicks, Andrew A

AU - Hattori, Nobutaka

AU - Jeon, Beom

AU - Lesage, Suzanne

AU - Lill, Christina M

AU - Lin, Juei-Jueng

AU - Lynch, Timothy

AU - Lichtner, Peter

AU - Lang, Anthony E

AU - Mok, Vincent

AU - Jasinska-Myga, Barbara

AU - Mellick, George D

AU - Morrison, Karen E

AU - Opala, Grzegorz

AU - Pramstaller, Peter P

AU - Pichler, Irene

AU - Park, Sung Sup

AU - Quattrone, Aldo

AU - Rogaeva, Ekaterina

AU - Ross, Owen A

AU - Stefanis, Leonidas

AU - Stockton, Joanne D

AU - Satake, Wataru

AU - Silburn, Peter A

AU - Theuns, Jessie

AU - Tan, Eng-King

AU - Toda, Tatsushi

AU - Tomiyama, Hiroyuki

AU - Uitti, Ryan J

AU - Wirdefeldt, Karin

AU - Wszolek, Zbigniew

AU - Xiromerisiou, Georgia

AU - Yueh, Kuo-Chu

AU - Genetic Epidemiology Of Parkinson's Disease (GEO-PD) Consortium

PY - 2012/8/14

Y1 - 2012/8/14

N2 - Eleven genetic loci have reached genome-wide significance in a recent meta-analysis of genome-wide association studies in Parkinson disease (PD) based on populations of Caucasian descent. The extent to which these genetic effects are consistent across different populations is unknown.

AB - Eleven genetic loci have reached genome-wide significance in a recent meta-analysis of genome-wide association studies in Parkinson disease (PD) based on populations of Caucasian descent. The extent to which these genetic effects are consistent across different populations is unknown.

KW - Aged

KW - Alleles

KW - Case-Control Studies

KW - Female

KW - Gene Frequency

KW - Genetic Loci

KW - Genetic Predisposition to Disease

KW - Genome-Wide Association Study

KW - Genotype

KW - Humans

KW - Male

KW - Middle Aged

KW - Parkinson Disease

KW - Polymorphism, Single Nucleotide

U2 - 10.1212/WNL.0b013e318264e353

DO - 10.1212/WNL.0b013e318264e353

M3 - Article

C2 - 22786590

SN - 0028-3878

VL - 79

SP - 659

EP - 667

JO - Neurology

JF - Neurology

IS - 7

ER -

Large-scale replication and heterogeneity in Parkinson disease genetic loci

Abstract

Keywords

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