Large-scale replication and heterogeneity in Parkinson disease genetic loci

Research output: Contribution to journalArticle

Authors

  • Manu Sharma
  • John P A Ioannidis
  • Jan O Aasly
  • Grazia Annesi
  • Alexis Brice
  • Christine Van Broeckhoven
  • Lars Bertram
  • Maria Bozi
  • David Crosiers
  • Carl E Clarke
  • Maurizio Facheris
  • Matthew Farrer
  • Gaetan Garraux
  • Suzana Gispert
  • Georg Auburger
  • Carles Vilariño-Güell
  • Georgios M Hadjigeorgiou
  • Andrew A Hicks
  • Nobutaka Hattori
  • Beom Jeon
  • Suzanne Lesage
  • Christina M Lill
  • Juei-Jueng Lin
  • Timothy Lynch
  • Peter Lichtner
  • Anthony E Lang
  • Vincent Mok
  • Barbara Jasinska-Myga
  • George D Mellick
  • Karen Morrison
  • Grzegorz Opala
  • Peter P Pramstaller
  • Irene Pichler
  • Sungjin Park
  • Aldo Quattrone
  • Ekaterina Rogaeva
  • Owen A Ross
  • Leonidas Stefanis
  • Joanne Stockton
  • Wataru Satake
  • Peter A Silburn
  • Jessie Theuns
  • Eng-King Tan
  • Tatsushi Toda
  • Hiroyuki Tomiyama
  • Ryan J Uitti
  • Karin Wirdefeldt
  • Zbigniew Wszolek
  • Georgia Xiromerisiou
  • Kuo-Chu Yueh
  • Genetic Epidemiology Of Parkinson's Disease (GEO-PD) Consortium

Colleges, School and Institutes

Abstract

Eleven genetic loci have reached genome-wide significance in a recent meta-analysis of genome-wide association studies in Parkinson disease (PD) based on populations of Caucasian descent. The extent to which these genetic effects are consistent across different populations is unknown.

Details

Original languageEnglish
Pages (from-to)659-67
Number of pages9
JournalNeurology
Volume79
Issue number7
Publication statusPublished - 14 Aug 2012

Keywords

  • Aged, Alleles, Case-Control Studies, Female, Gene Frequency, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Humans, Male, Middle Aged, Parkinson Disease, Polymorphism, Single Nucleotide