Large-Scale Network Topology Reveals Heterogeneity in Individuals With at Risk Mental State for Psychosis: Findings From the Longitudinal Youth-at-Risk Study

Research output: Contribution to journalArticlepeer-review


  • Chenhao Wang
  • Jimmy Lee
  • New Fei Ho
  • Joseph K W Lim
  • Joann S Poh
  • Gurpreet Rekhi
  • Ranga Krishnan
  • Richard S E Keefe
  • R Alison Adcock
  • Alex Fornito
  • Michael W L Chee
  • Juan Zhou

Colleges, School and Institutes

External organisations

  • Melbourne Neuropsychiatry Centre, University of Melbourne and Melbourne Health


Emerging evidence demonstrates heterogeneity in clinical outcomes of prodromal psychosis that only a small percentage of at-risk individuals eventually progress to full-blown psychosis. To examine the neurobiological underpinnings of this heterogeneity from a network perspective, we tested whether the early patterns of large-scale brain network topology were associated with risk of developing clinical psychosis. Task-free functional MRI data were acquired from subjects with At Risk Mental State (ARMS) for psychosis and healthy controls (HC). All individuals had no history of drug abuse and were not on antipsychotics. We performed functional connectomics analysis to identify patterns of system-level functional brain dysconnectivity associated with ARMS individuals with different outcomes. In comparison to HC and ARMS who did not transition to psychosis at follow-up (ARMS-NT), ARMS individuals who did (ARMS-T) showed marked brain functional dysconnectivity, characterized by loss of network segregation and disruption of network communities, especially the salience, default, dorsal attention, sensorimotor and limbic networks (P < 0.05 FWE-corrected, Cohen's d > 1.00), and was associated with baseline symptom severity. In contrast, we did not observe connectivity differences between ARMS-NT and HC individuals. Taken together, these results suggest a possible large-scale functional brain network topology phenotype related to risk of psychosis transition in ARMS individuals.


Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalCerebral Cortex
Early online date27 Oct 2017
Publication statusE-pub ahead of print - 27 Oct 2017


  • at risk for psychosis , brain connectomics , functional connectivity , LYRIKS , transition to psychosis