Lactate modulation of immune responses in inflammatory versus tumour microenvironments

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Lactate modulation of immune responses in inflammatory versus tumour microenvironments. / Certo, Michelangelo; Tsai, Chin-Hsien; Pucino, Valentina; Ho, Ping-Chih; Mauro, Claudio.

In: Nature Reviews Immunology, 24.08.2020.

Research output: Contribution to journalReview articlepeer-review

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@article{15438ca01fbb4725949af2c870364f34,
title = "Lactate modulation of immune responses in inflammatory versus tumour microenvironments",
abstract = "The microenvironment in cancerous tissues is immunosuppressive and pro-tumorigenic, whereas the microenvironment of tissues affected by chronic inflammatory disease is pro-inflammatory and anti-resolution. Despite these opposing immunological states, the metabolic states in the tissue microenvironments of cancer and inflammatory diseases are similar: both are hypoxic, show elevated levels of lactate and other metabolic by-products and have low levels of nutrients. In this Review, we describe how the bioavailability of lactate differs in the microenvironments of tumours and inflammatory diseases compared with normal tissues, thus contributing to the establishment of specific immunological states in disease. A clear understanding of the metabolic signature of tumours and inflammatory diseases will enable therapeutic intervention aimed at resetting the bioavailability of metabolites and correcting the dysregulated immunological state, triggering beneficial cytotoxic, inflammatory responses in tumours and immunosuppressive responses in chronic inflammation.",
author = "Michelangelo Certo and Chin-Hsien Tsai and Valentina Pucino and Ping-Chih Ho and Claudio Mauro",
year = "2020",
month = aug,
day = "24",
doi = "10.1038/s41577-020-0406-2",
language = "English",
journal = "Nature Reviews Immunology",
issn = "1474-1733",
publisher = "Nature Publishing Group",

}

RIS

TY - JOUR

T1 - Lactate modulation of immune responses in inflammatory versus tumour microenvironments

AU - Certo, Michelangelo

AU - Tsai, Chin-Hsien

AU - Pucino, Valentina

AU - Ho, Ping-Chih

AU - Mauro, Claudio

PY - 2020/8/24

Y1 - 2020/8/24

N2 - The microenvironment in cancerous tissues is immunosuppressive and pro-tumorigenic, whereas the microenvironment of tissues affected by chronic inflammatory disease is pro-inflammatory and anti-resolution. Despite these opposing immunological states, the metabolic states in the tissue microenvironments of cancer and inflammatory diseases are similar: both are hypoxic, show elevated levels of lactate and other metabolic by-products and have low levels of nutrients. In this Review, we describe how the bioavailability of lactate differs in the microenvironments of tumours and inflammatory diseases compared with normal tissues, thus contributing to the establishment of specific immunological states in disease. A clear understanding of the metabolic signature of tumours and inflammatory diseases will enable therapeutic intervention aimed at resetting the bioavailability of metabolites and correcting the dysregulated immunological state, triggering beneficial cytotoxic, inflammatory responses in tumours and immunosuppressive responses in chronic inflammation.

AB - The microenvironment in cancerous tissues is immunosuppressive and pro-tumorigenic, whereas the microenvironment of tissues affected by chronic inflammatory disease is pro-inflammatory and anti-resolution. Despite these opposing immunological states, the metabolic states in the tissue microenvironments of cancer and inflammatory diseases are similar: both are hypoxic, show elevated levels of lactate and other metabolic by-products and have low levels of nutrients. In this Review, we describe how the bioavailability of lactate differs in the microenvironments of tumours and inflammatory diseases compared with normal tissues, thus contributing to the establishment of specific immunological states in disease. A clear understanding of the metabolic signature of tumours and inflammatory diseases will enable therapeutic intervention aimed at resetting the bioavailability of metabolites and correcting the dysregulated immunological state, triggering beneficial cytotoxic, inflammatory responses in tumours and immunosuppressive responses in chronic inflammation.

U2 - 10.1038/s41577-020-0406-2

DO - 10.1038/s41577-020-0406-2

M3 - Review article

C2 - 32839570

JO - Nature Reviews Immunology

JF - Nature Reviews Immunology

SN - 1474-1733

ER -