Lactate: fueling the fire starter

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Lactate: fueling the fire starter. / Certo, Michelangelo; Marone, Giancarlo; de Paulis, Amato; Mauro, Claudio; Pucino, Valentina.

In: Wires Systems Biology and Medicine, Vol. 12, No. 3, e1474, 13.04.2020, p. 1-15.

Research output: Contribution to journalReview articlepeer-review

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Certo, Michelangelo ; Marone, Giancarlo ; de Paulis, Amato ; Mauro, Claudio ; Pucino, Valentina. / Lactate: fueling the fire starter. In: Wires Systems Biology and Medicine. 2020 ; Vol. 12, No. 3. pp. 1-15.

Bibtex

@article{a460c1e4da8f4031bb8dd9b6c3b2d28c,
title = "Lactate:: fueling the fire starter",
abstract = "It is becoming increasingly appreciated that intermediates of metabolic pathways, besides their anabolic and catabolic functions, can act as signaling molecules and influence the outcome of immune responses. Although lactate was previously considered as a waste product of glucose metabolism, accumulating evidence has highlighted its pivotal role in regulating diverse biological processes, including immune cell polarization, differentiation and effector functions. In addition, lactate is a key player in modulating tumor immune surveillance. Hence, targeting lactate‐induced signaling pathways is a promising tool to reduce inflammation, to prevent autoimmunity and to restore anti‐tumor immune response.",
keywords = "immunity, inflammation, lactate, metabolism, tumor",
author = "Michelangelo Certo and Giancarlo Marone and {de Paulis}, Amato and Claudio Mauro and Valentina Pucino",
year = "2020",
month = apr,
day = "13",
doi = "10.1002/wsbm.1474",
language = "English",
volume = "12",
pages = "1--15",
journal = "Wires Systems Biology and Medicine",
number = "3",

}

RIS

TY - JOUR

T1 - Lactate:

T2 - fueling the fire starter

AU - Certo, Michelangelo

AU - Marone, Giancarlo

AU - de Paulis, Amato

AU - Mauro, Claudio

AU - Pucino, Valentina

PY - 2020/4/13

Y1 - 2020/4/13

N2 - It is becoming increasingly appreciated that intermediates of metabolic pathways, besides their anabolic and catabolic functions, can act as signaling molecules and influence the outcome of immune responses. Although lactate was previously considered as a waste product of glucose metabolism, accumulating evidence has highlighted its pivotal role in regulating diverse biological processes, including immune cell polarization, differentiation and effector functions. In addition, lactate is a key player in modulating tumor immune surveillance. Hence, targeting lactate‐induced signaling pathways is a promising tool to reduce inflammation, to prevent autoimmunity and to restore anti‐tumor immune response.

AB - It is becoming increasingly appreciated that intermediates of metabolic pathways, besides their anabolic and catabolic functions, can act as signaling molecules and influence the outcome of immune responses. Although lactate was previously considered as a waste product of glucose metabolism, accumulating evidence has highlighted its pivotal role in regulating diverse biological processes, including immune cell polarization, differentiation and effector functions. In addition, lactate is a key player in modulating tumor immune surveillance. Hence, targeting lactate‐induced signaling pathways is a promising tool to reduce inflammation, to prevent autoimmunity and to restore anti‐tumor immune response.

KW - immunity

KW - inflammation

KW - lactate

KW - metabolism

KW - tumor

UR - http://www.scopus.com/inward/record.url?scp=85076791865&partnerID=8YFLogxK

U2 - 10.1002/wsbm.1474

DO - 10.1002/wsbm.1474

M3 - Review article

C2 - 31840439

VL - 12

SP - 1

EP - 15

JO - Wires Systems Biology and Medicine

JF - Wires Systems Biology and Medicine

IS - 3

M1 - e1474

ER -