Lack of CD151/integrin α3β1 complex is predictive of poor outcome in node-negative lobular breast carcinoma: opposing roles of CD151 in invasive lobular and ductal breast cancers

Research output: Contribution to journalArticle

Authors

  • Piotr Potemski
  • Magdalena Krakowska
  • Magdalena Mieszkowska
  • Shalini Chaudhri
  • Radzisław Kordek
  • Robert Kubiak
  • Valerie Speirs
  • Andrew Hanby

Colleges, School and Institutes

External organisations

  • Department of Chemotherapy, Medical University of Łódź and M. Kopernik Memorial Hospital, ul. Paderewskiego 4, 93-509 Łódź, Poland
  • Department of Molecular Enzymology, Intercollegiate Faculty of Biotechnology, Medical University of Gdańsk, ul. Dębinki 1, 80-210 Gdansk, Poland
  • Department of Molecular Enzymology, Intercollegiate Faculty of Biotechnology, Medical University of Gdańsk, ul. Dębinki 1, 80-210 Gdansk, Poland
  • 1Department of Pathology, Medical University of Łódź, ul. Pomorska 251, 92-213 Łódź, Poland
  • University of Leeds

Abstract


Background:

The proposed involvement of CD151 in breast cancer (BCa) progression is based on findings from studies in invasive ductal carcinoma (IDC). The IDC and invasive lobular carcinoma (ILC) represent distinct disease entities. Here we evaluated clinical significance of CD151 alone and in association with integrin α3β1 in patients with ILC in context of the data of our recent IDC study.


Methods:

Expression of CD151 and/or integrin α3β1 was evaluated in ILC samples (N=117) using immunohistochemistry. The findings were analysed in relation to our results from an IDC cohort (N=182) demonstrating a prognostic value of an expression of CD151/integrin α3β1 complex in patients with HER2-negative tumours.


Results:

Unlike in the IDCs, neither CD151 nor CD151/α3β1 complex showed any correlation with any of the ILC characteristics. Lack of both CD151 and α3β1 was significantly correlated with poor survival (P=0.034) in lymph node-negative ILC N(−) cases. The CD151−/α3β1− patients had 3.12-fold higher risk of death from BCa in comparison with the rest of the ILC N(−) patients.


Conclusions:

Biological role of CD151/α3β1 varies between ILC and IDC. Assessment of CD151/α3β1 might help to identify ILC N(−) patients with increased risk of distant metastases.

Details

Original languageEnglish
Pages (from-to)1350-1357
JournalBritish Journal of Cancer
Volume113
Issue number9
Early online date29 Sep 2015
Publication statusPublished - 3 Nov 2015

Keywords

  • invasive lobular carcinoma, node negative, CD151, integrin α3β1