Kinetin Riboside and Its ProTides Activate the Parkinson's Disease Associated PTEN-Induced Putative Kinase 1 (PINK1) Independent of Mitochondrial Depolarization
Research output: Contribution to journal › Article
Colleges, School and Institutes
- University of Dundee
- School of Pharmacy, University of Birmingham , Birmingham, B15 2TT, U.K.
- Cardiff University
- School of Chemistry, University of Birmingham , Birmingham, B15 2TT, U.K.
Since loss of function mutations of PINK1 lead to early onset Parkinson's disease, there has been growing interest in the discovery of small molecules that amplify the kinase activity of PINK1. We herein report the design, synthesis, serum stability, and hydrolysis of four kinetin riboside ProTides. These ProTides, along with kinetin riboside, activated PINK1 in cells independent of mitochondrial depolarization. This highlights the potential of modified nucleosides and their phosphate prodrugs as treatments for neurodegenerative diseases.
|Number of pages||7|
|Journal||Journal of Medicinal Chemistry|
|Early online date||21 Mar 2017|
|Publication status||Published - 27 Apr 2017|