Issues surrounding standard cytotoxicity testing for assessing activity of non-covalent DNA-binding metallo-drugs

Research output: Contribution to journalArticle

Colleges, School and Institutes

Abstract

Investigating the methods commonly used to evaluate in vitro cytotoxicity of novel compounds, specifically non-covalent DNA binders, identifies that these methods may not be appropriate. The level of anticancer activity depends not only on the incubation time but also on the absolute amount (number of moles) of drug compound applied, rather than the concentration.

Details

Original languageEnglish
Pages (from-to)2772-2774
Number of pages3
JournalDalton Transactions
Volume39
Issue number11
Publication statusPublished - 1 Jan 2010