Isolating response inhibition in the brain: Parietal versus frontal contribution

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Isolating response inhibition in the brain : Parietal versus frontal contribution. / Kolodny, Tamar; Mevorach, Carmel; Shalev, Llilach.

In: Cortex, Vol. 88, 03.2017, p. 173-185.

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Kolodny, Tamar ; Mevorach, Carmel ; Shalev, Llilach. / Isolating response inhibition in the brain : Parietal versus frontal contribution. In: Cortex. 2017 ; Vol. 88. pp. 173-185.

Bibtex

@article{cd519b664bff49d4bdafe81a4c3e34ff,
title = "Isolating response inhibition in the brain: Parietal versus frontal contribution",
abstract = "Response inhibition is a main function of cognitive control and its neural substrates have been studied extensively. However, it is still a question whether previous brain imaging investigations were successful in isolating specific response inhibition activation. In the current study we attempted to pinpoint response inhibition in the brain using a Go/No-go task and fMRI, by contrasting rare-No-go trials with prevalent-No-go trials. Although inhibition is required in all No-go trials, task variants with rare-No-go cases (25%) create a prepotent response which elicits a strong demand for inhibition, while task variants with prevalent-No-go cases (75%) require very little inhibition effort. Since the neural activation in this design is extracted solely from No-go trials, differing only in the extent of inhibitory demand, the analysis avoids contamination of the data with motor effects or visual factors. Using this experimental design we highlight the contribution of the parietal cortex (bilaterally) to inhibitory processes, while casting doubts about the specificity of frontal activation in such processes. Future studies are required to verify that bilateral IPS and left temporo-parietal junction activations could be markers of inhibitory control.",
keywords = "Response inhibition, Go/No-go, fMRI, Intraparietal sulcus, Temporo-parietal junction",
author = "Tamar Kolodny and Carmel Mevorach and Llilach Shalev",
year = "2017",
month = mar,
doi = "10.1016/j.cortex.2016.12.012",
language = "English",
volume = "88",
pages = "173--185",
journal = "Cortex",
issn = "0010-9452",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Isolating response inhibition in the brain

T2 - Parietal versus frontal contribution

AU - Kolodny, Tamar

AU - Mevorach, Carmel

AU - Shalev, Llilach

PY - 2017/3

Y1 - 2017/3

N2 - Response inhibition is a main function of cognitive control and its neural substrates have been studied extensively. However, it is still a question whether previous brain imaging investigations were successful in isolating specific response inhibition activation. In the current study we attempted to pinpoint response inhibition in the brain using a Go/No-go task and fMRI, by contrasting rare-No-go trials with prevalent-No-go trials. Although inhibition is required in all No-go trials, task variants with rare-No-go cases (25%) create a prepotent response which elicits a strong demand for inhibition, while task variants with prevalent-No-go cases (75%) require very little inhibition effort. Since the neural activation in this design is extracted solely from No-go trials, differing only in the extent of inhibitory demand, the analysis avoids contamination of the data with motor effects or visual factors. Using this experimental design we highlight the contribution of the parietal cortex (bilaterally) to inhibitory processes, while casting doubts about the specificity of frontal activation in such processes. Future studies are required to verify that bilateral IPS and left temporo-parietal junction activations could be markers of inhibitory control.

AB - Response inhibition is a main function of cognitive control and its neural substrates have been studied extensively. However, it is still a question whether previous brain imaging investigations were successful in isolating specific response inhibition activation. In the current study we attempted to pinpoint response inhibition in the brain using a Go/No-go task and fMRI, by contrasting rare-No-go trials with prevalent-No-go trials. Although inhibition is required in all No-go trials, task variants with rare-No-go cases (25%) create a prepotent response which elicits a strong demand for inhibition, while task variants with prevalent-No-go cases (75%) require very little inhibition effort. Since the neural activation in this design is extracted solely from No-go trials, differing only in the extent of inhibitory demand, the analysis avoids contamination of the data with motor effects or visual factors. Using this experimental design we highlight the contribution of the parietal cortex (bilaterally) to inhibitory processes, while casting doubts about the specificity of frontal activation in such processes. Future studies are required to verify that bilateral IPS and left temporo-parietal junction activations could be markers of inhibitory control.

KW - Response inhibition

KW - Go/No-go

KW - fMRI

KW - Intraparietal sulcus

KW - Temporo-parietal junction

U2 - 10.1016/j.cortex.2016.12.012

DO - 10.1016/j.cortex.2016.12.012

M3 - Article

VL - 88

SP - 173

EP - 185

JO - Cortex

JF - Cortex

SN - 0010-9452

ER -