Is the higher risk of cardiovascular disease amongst South Asian populations linked to abnormalities of haemoglobin? A preliminary case control study

Research output: Contribution to journalArticlepeer-review

Authors

  • Jeetesh V Patel
  • Brian Gammon
  • Inessa Tracey
  • Adam Lovick
  • Charlotte A Scarff
  • James H Scrivens
  • Elizabeth A Hughes

Abstract

The elevated burden of cardiovascular disease (CVD) amongst South Asian populations is a complex and multi-factorial phenomenon. South Asians evolved from environments where malaria was endemic, and while haemoglobin disorders frequent this group, a link to CVD has not been described. Using a case-control feasibility study, haemoglobin abnormalities identified by mass spectrometry were compared between South Asian patients with CVD (n = 72) and non-CVD controls (n = 84). Carotid-artery intima media thickness (CIMT) was used as a marker of vascular damage. Ultracentrifugation was used to separate lipoprotein subfractions, which were analysed for iron. Haemoglobin anomalies were more frequent for CVD patients than controls (34.7% vs. 14.3%, P 

Bibliographic note

Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

Details

Original languageEnglish
Pages (from-to)198-200
Number of pages3
JournalAtherosclerosis
Volume226
Issue number1
Publication statusPublished - 2013