Is leg length a biomarker of childhood conditions in older chinese women? The Guangzhou biobank cohort study

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Is leg length a biomarker of childhood conditions in older chinese women? The Guangzhou biobank cohort study. / Schooling, CM; Jiang, CQ; Heys, M; Zhang, WS; Lao, XQ; Adab, Peymane; Cowling, BJ; Thomas, GN; Cheng, Kar; Lam, TH; Leung, GM.

In: Journal of Epidemiology and Community Health, Vol. 62, No. 2, 01.02.2008, p. 160-167.

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Schooling, CM, Jiang, CQ, Heys, M, Zhang, WS, Lao, XQ, Adab, P, Cowling, BJ, Thomas, GN, Cheng, K, Lam, TH & Leung, GM 2008, 'Is leg length a biomarker of childhood conditions in older chinese women? The Guangzhou biobank cohort study', Journal of Epidemiology and Community Health, vol. 62, no. 2, pp. 160-167. https://doi.org/10.1136/jech.2006.058917

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Schooling, CM ; Jiang, CQ ; Heys, M ; Zhang, WS ; Lao, XQ ; Adab, Peymane ; Cowling, BJ ; Thomas, GN ; Cheng, Kar ; Lam, TH ; Leung, GM. / Is leg length a biomarker of childhood conditions in older chinese women? The Guangzhou biobank cohort study. In: Journal of Epidemiology and Community Health. 2008 ; Vol. 62, No. 2. pp. 160-167.

Bibtex

@article{ae752c5536ea4b189928c6f764ffeda2,
title = "Is leg length a biomarker of childhood conditions in older chinese women? The Guangzhou biobank cohort study",
abstract = "Objective: In developed western populations longer legs have been shown to be a biomarker of better early childhood conditions. It was hypothesised that in transitioning populations better childhood conditions may bring forward puberty and thus decrease leg length, counteracting the overall positive effect of a favourable childhood environment on leg growth. Design: Structural equation modelling was used to assess the interrelationship of age, education, father's job, age of menarche and leg length in a cross-sectional sample of 7273 Chinese women aged at least 50 years from the Guangzhou Biobank Cohort Study. Results: Leg length had no significant association with education or father's occupation on bivariable testing. After including age of menarche in the model, education was associated with longer legs (0.45 cm longer per 10 years of education, 95% CI 0.20 to 0.71). Education was also associated with younger age of menarche (1.21 years younger per 10 years of education, 95% CI 1.09 to 1.34), which was in turn associated with shorter legs (0.23 cm shorter per year of menarche earlier, 95% CI 0.18 to 0.27). Conclusions: In older Chinese women leg length is not a universal biomarker of childhood conditions, when proxied by her educational level and father's occupation. Nutritionally driven epigenetic influences operating over generations may constrain growth in very recently developed populations. Given the impact of childhood conditions on health, and the dearth of long-term records outside the industrialised world, a greater understanding of the influences on growth in the developing world is required.",
author = "CM Schooling and CQ Jiang and M Heys and WS Zhang and XQ Lao and Peymane Adab and BJ Cowling and GN Thomas and Kar Cheng and TH Lam and GM Leung",
year = "2008",
month = feb,
day = "1",
doi = "10.1136/jech.2006.058917",
language = "English",
volume = "62",
pages = "160--167",
journal = "Journal of Epidemiology and Community Health",
issn = "0143-005X",
publisher = "BMJ Publishing Group",
number = "2",

}

RIS

TY - JOUR

T1 - Is leg length a biomarker of childhood conditions in older chinese women? The Guangzhou biobank cohort study

AU - Schooling, CM

AU - Jiang, CQ

AU - Heys, M

AU - Zhang, WS

AU - Lao, XQ

AU - Adab, Peymane

AU - Cowling, BJ

AU - Thomas, GN

AU - Cheng, Kar

AU - Lam, TH

AU - Leung, GM

PY - 2008/2/1

Y1 - 2008/2/1

N2 - Objective: In developed western populations longer legs have been shown to be a biomarker of better early childhood conditions. It was hypothesised that in transitioning populations better childhood conditions may bring forward puberty and thus decrease leg length, counteracting the overall positive effect of a favourable childhood environment on leg growth. Design: Structural equation modelling was used to assess the interrelationship of age, education, father's job, age of menarche and leg length in a cross-sectional sample of 7273 Chinese women aged at least 50 years from the Guangzhou Biobank Cohort Study. Results: Leg length had no significant association with education or father's occupation on bivariable testing. After including age of menarche in the model, education was associated with longer legs (0.45 cm longer per 10 years of education, 95% CI 0.20 to 0.71). Education was also associated with younger age of menarche (1.21 years younger per 10 years of education, 95% CI 1.09 to 1.34), which was in turn associated with shorter legs (0.23 cm shorter per year of menarche earlier, 95% CI 0.18 to 0.27). Conclusions: In older Chinese women leg length is not a universal biomarker of childhood conditions, when proxied by her educational level and father's occupation. Nutritionally driven epigenetic influences operating over generations may constrain growth in very recently developed populations. Given the impact of childhood conditions on health, and the dearth of long-term records outside the industrialised world, a greater understanding of the influences on growth in the developing world is required.

AB - Objective: In developed western populations longer legs have been shown to be a biomarker of better early childhood conditions. It was hypothesised that in transitioning populations better childhood conditions may bring forward puberty and thus decrease leg length, counteracting the overall positive effect of a favourable childhood environment on leg growth. Design: Structural equation modelling was used to assess the interrelationship of age, education, father's job, age of menarche and leg length in a cross-sectional sample of 7273 Chinese women aged at least 50 years from the Guangzhou Biobank Cohort Study. Results: Leg length had no significant association with education or father's occupation on bivariable testing. After including age of menarche in the model, education was associated with longer legs (0.45 cm longer per 10 years of education, 95% CI 0.20 to 0.71). Education was also associated with younger age of menarche (1.21 years younger per 10 years of education, 95% CI 1.09 to 1.34), which was in turn associated with shorter legs (0.23 cm shorter per year of menarche earlier, 95% CI 0.18 to 0.27). Conclusions: In older Chinese women leg length is not a universal biomarker of childhood conditions, when proxied by her educational level and father's occupation. Nutritionally driven epigenetic influences operating over generations may constrain growth in very recently developed populations. Given the impact of childhood conditions on health, and the dearth of long-term records outside the industrialised world, a greater understanding of the influences on growth in the developing world is required.

U2 - 10.1136/jech.2006.058917

DO - 10.1136/jech.2006.058917

M3 - Article

VL - 62

SP - 160

EP - 167

JO - Journal of Epidemiology and Community Health

JF - Journal of Epidemiology and Community Health

SN - 0143-005X

IS - 2

ER -