TY - JOUR
T1 - Iodine Status during Pregnancy in a Region of Mild-to-Moderate Iodine Deficiency is not Associated with Adverse Obstetric Outcomes; Results from the Avon Longitudinal Study of Parents and Children (ALSPAC)
AU - Torlinska, Barbara
AU - Bath, Sarah C
AU - Janjua, Aisha
AU - Boelaert, Kristien
AU - Chan, Shiao-Yng
PY - 2018/3/1
Y1 - 2018/3/1
N2 - Severe iodine deficiency during pregnancy has been associated with pregnancy/neonatal loss, and adverse pregnancy outcomes; however, the impact of mild–to–moderate iodine insufficiency, though prevalent in pregnancy, is not well-documented. We assessed whether mild iodine deficiency during pregnancy was associated with pregnancy/infant loss, or with other adverse pregnancy
outcomes. We used samples and data from the Avon Longitudinal Study of Parents and Children (ALSPAC), from 3140 singleton pregnancies and from a further 42 women with pregnancy/infant loss. The group was classified as mildly-to-moderately iodine deficient with a median urinary iodine
concentration of 95.3 g/L (IQR 57.0–153.0; median urinary iodine-to-creatinine ratio (UI/Creat) 124 g/g, IQR 82–198). The likelihood of pregnancy/infant loss was not different across four UI/Creat groups (<50, 50–149, 150–250, >250 g/g). The incidence of pre-eclampsia, non-proteinuric gestational
hypertension, gestational diabetes, glycosuria, anaemia, post-partum haemorrhage, preterm delivery, mode of delivery, being small for gestational age, and large for gestational age did not differ significantly among UI/Creat groups, nor were there any significant differences in the median UI/Creat. We conclude that maternal iodine status was not associated with adverse pregnancy
outcomes in a mildly-to-moderately iodine-deficient pregnant population. However, in view of the low number of women with pregnancy/infant loss in our study, further research is required.
Keywords: iodine; pregnancy; obstetric; UK; Avon Longitudinal Study of Parents and Children
(ALSPAC)
AB - Severe iodine deficiency during pregnancy has been associated with pregnancy/neonatal loss, and adverse pregnancy outcomes; however, the impact of mild–to–moderate iodine insufficiency, though prevalent in pregnancy, is not well-documented. We assessed whether mild iodine deficiency during pregnancy was associated with pregnancy/infant loss, or with other adverse pregnancy
outcomes. We used samples and data from the Avon Longitudinal Study of Parents and Children (ALSPAC), from 3140 singleton pregnancies and from a further 42 women with pregnancy/infant loss. The group was classified as mildly-to-moderately iodine deficient with a median urinary iodine
concentration of 95.3 g/L (IQR 57.0–153.0; median urinary iodine-to-creatinine ratio (UI/Creat) 124 g/g, IQR 82–198). The likelihood of pregnancy/infant loss was not different across four UI/Creat groups (<50, 50–149, 150–250, >250 g/g). The incidence of pre-eclampsia, non-proteinuric gestational
hypertension, gestational diabetes, glycosuria, anaemia, post-partum haemorrhage, preterm delivery, mode of delivery, being small for gestational age, and large for gestational age did not differ significantly among UI/Creat groups, nor were there any significant differences in the median UI/Creat. We conclude that maternal iodine status was not associated with adverse pregnancy
outcomes in a mildly-to-moderately iodine-deficient pregnant population. However, in view of the low number of women with pregnancy/infant loss in our study, further research is required.
Keywords: iodine; pregnancy; obstetric; UK; Avon Longitudinal Study of Parents and Children
(ALSPAC)
KW - iodine
KW - pregnancy
KW - obstetric
KW - UK
KW - Avon Longitudinal Study of Parents and Children (ALSPAC)
U2 - 10.3390/nu10030291
DO - 10.3390/nu10030291
M3 - Article
SN - 2072-6643
VL - 10
JO - Nutrients
JF - Nutrients
IS - 3
M1 - 291
ER -