Investigation of formulation and process of lyophilised orally disintegrating tablet (ODT) using novel amino acid combination

Farhan AlHusban; Amr M. Elshaer; Jiteen H. Kansara; Alan M. Smith; Liam M. Grover; Yvonne Perrie; Afzal R. Mohammed

doi:10.3390/pharmaceutics2010001

Investigation of formulation and process of lyophilised orally disintegrating tablet (ODT) using novel amino acid combination

Farhan AlHusban, Amr M. Elshaer, Jiteen H. Kansara, Alan M. Smith, Liam M. Grover, Yvonne Perrie, Afzal R. Mohammed

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Lyophilised orally disintegrating tablets (ODTs) have achieved a great success in overcoming dysphagia associated with conventional solid dosage forms. However, the extensive use of saccharides within the formulation limits their use in treatment of chronic illnesses. The current study demonstrates the feasibility of using combination of proline and serine to formulate zero sacharide ODTs and investigates the effect of freezing protocol on sublimation rate and tablets characteristics. The results showed that inclusion of proline and serine improved ODT properties when compared to individual counterparts. Additionally, annealing the ODTs facilitated the sublimation process and shortened the disintegration time.

Original language	English
Pages (from-to)	1-17
Number of pages	17
Journal	Pharmaceutics
Volume	2
Issue number	1
DOIs	https://doi.org/10.3390/pharmaceutics2010001
Publication status	Published - 1 Mar 2010

Keywords

Annealing
Lyophilisation
Orally disintegrating tablets
Proline
Serine
Sublimation rate

ASJC Scopus subject areas

Pharmaceutical Science

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10.3390/pharmaceutics2010001

Cite this

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abstract = "Lyophilised orally disintegrating tablets (ODTs) have achieved a great success in overcoming dysphagia associated with conventional solid dosage forms. However, the extensive use of saccharides within the formulation limits their use in treatment of chronic illnesses. The current study demonstrates the feasibility of using combination of proline and serine to formulate zero sacharide ODTs and investigates the effect of freezing protocol on sublimation rate and tablets characteristics. The results showed that inclusion of proline and serine improved ODT properties when compared to individual counterparts. Additionally, annealing the ODTs facilitated the sublimation process and shortened the disintegration time.",

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AU - AlHusban, Farhan

AU - Elshaer, Amr M.

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AU - Smith, Alan M.

AU - Grover, Liam M.

AU - Perrie, Yvonne

AU - Mohammed, Afzal R.

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AB - Lyophilised orally disintegrating tablets (ODTs) have achieved a great success in overcoming dysphagia associated with conventional solid dosage forms. However, the extensive use of saccharides within the formulation limits their use in treatment of chronic illnesses. The current study demonstrates the feasibility of using combination of proline and serine to formulate zero sacharide ODTs and investigates the effect of freezing protocol on sublimation rate and tablets characteristics. The results showed that inclusion of proline and serine improved ODT properties when compared to individual counterparts. Additionally, annealing the ODTs facilitated the sublimation process and shortened the disintegration time.

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KW - Lyophilisation

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Investigation of formulation and process of lyophilised orally disintegrating tablet (ODT) using novel amino acid combination

Abstract

Keywords

ASJC Scopus subject areas

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