Investigating the effect of ethnicity on IVF outcome

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Investigating the effect of ethnicity on IVF outcome. / Dhillon, Rima K; Smith, Paul P; Malhas, Rosamund; Harb, Hoda M; Gallos, Ioannis D; Dowell, Ken; Fishel, Simon; Deeks, Jonathan; Coomarasamy, Aravinthan; Coomarasamy, Aravinthan.

In: Reproductive BioMedicine Online, Vol. 31, No. 3, 09.2015, p. 356–363.

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@article{9de6e9d8f68d488ca8f029a32ebcf801,
title = "Investigating the effect of ethnicity on IVF outcome",
abstract = "Success rates for IVF among women from different ethnic groups have been inconclusive. In this study, the relationship between ethnicity and IVF outcome was investigated. Results of a cohort study analysing 13,473 first cycles were compared with the results of meta-analysed data from 16 published studies. Adjustment was made for age, body-mass index, cause of infertility, duration of infertility, previous live birth, previous spontaneous abortion and number of embryos transferred. Black and South Asian women were found to have lower live birth rates compared with White women: Black versus White (OR 0.42 [0.25 to 0.70]; P = 0.001); South Asian versus White (OR 0.80 [0.65t o 0.99]; P = 0.04). Black women had significantly lower clinical pregnancy rates compared with White women (OR 0.41 [0.25 to 9 0.67]; P < 0.001). The meta-analysed results also showed that Black and South Asian women had statistically significant reduced odds of live birth (OR 0.62 [0.55 to 0.71); P < 0.001 and OR 0.66 [0.52 to 0.85); P = 0.001, respectively). Black and South Asian women seem to have the poorest outcome, which is not explained by the commonly known confounders. Future research needs to investigate the possible explanations for this difference and improve IVF outcome for all women.",
keywords = "assisted conception, ethnicity, in-vitro fertilisation, race",
author = "Dhillon, {Rima K} and Smith, {Paul P} and Rosamund Malhas and Harb, {Hoda M} and Gallos, {Ioannis D} and Ken Dowell and Simon Fishel and Jonathan Deeks and Aravinthan Coomarasamy and Aravinthan Coomarasamy",
note = "Copyright {\textcopyright} 2015 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.",
year = "2015",
month = sep,
doi = "10.1016/j.rbmo.2015.05.015",
language = "English",
volume = "31",
pages = "356–363",
journal = "Reproductive BioMedicine Online",
issn = "1472-6483",
publisher = "Elsevier",
number = "3",

}

RIS

TY - JOUR

T1 - Investigating the effect of ethnicity on IVF outcome

AU - Dhillon, Rima K

AU - Smith, Paul P

AU - Malhas, Rosamund

AU - Harb, Hoda M

AU - Gallos, Ioannis D

AU - Dowell, Ken

AU - Fishel, Simon

AU - Deeks, Jonathan

AU - Coomarasamy, Aravinthan

AU - Coomarasamy, Aravinthan

N1 - Copyright © 2015 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

PY - 2015/9

Y1 - 2015/9

N2 - Success rates for IVF among women from different ethnic groups have been inconclusive. In this study, the relationship between ethnicity and IVF outcome was investigated. Results of a cohort study analysing 13,473 first cycles were compared with the results of meta-analysed data from 16 published studies. Adjustment was made for age, body-mass index, cause of infertility, duration of infertility, previous live birth, previous spontaneous abortion and number of embryos transferred. Black and South Asian women were found to have lower live birth rates compared with White women: Black versus White (OR 0.42 [0.25 to 0.70]; P = 0.001); South Asian versus White (OR 0.80 [0.65t o 0.99]; P = 0.04). Black women had significantly lower clinical pregnancy rates compared with White women (OR 0.41 [0.25 to 9 0.67]; P < 0.001). The meta-analysed results also showed that Black and South Asian women had statistically significant reduced odds of live birth (OR 0.62 [0.55 to 0.71); P < 0.001 and OR 0.66 [0.52 to 0.85); P = 0.001, respectively). Black and South Asian women seem to have the poorest outcome, which is not explained by the commonly known confounders. Future research needs to investigate the possible explanations for this difference and improve IVF outcome for all women.

AB - Success rates for IVF among women from different ethnic groups have been inconclusive. In this study, the relationship between ethnicity and IVF outcome was investigated. Results of a cohort study analysing 13,473 first cycles were compared with the results of meta-analysed data from 16 published studies. Adjustment was made for age, body-mass index, cause of infertility, duration of infertility, previous live birth, previous spontaneous abortion and number of embryos transferred. Black and South Asian women were found to have lower live birth rates compared with White women: Black versus White (OR 0.42 [0.25 to 0.70]; P = 0.001); South Asian versus White (OR 0.80 [0.65t o 0.99]; P = 0.04). Black women had significantly lower clinical pregnancy rates compared with White women (OR 0.41 [0.25 to 9 0.67]; P < 0.001). The meta-analysed results also showed that Black and South Asian women had statistically significant reduced odds of live birth (OR 0.62 [0.55 to 0.71); P < 0.001 and OR 0.66 [0.52 to 0.85); P = 0.001, respectively). Black and South Asian women seem to have the poorest outcome, which is not explained by the commonly known confounders. Future research needs to investigate the possible explanations for this difference and improve IVF outcome for all women.

KW - assisted conception

KW - ethnicity

KW - in-vitro fertilisation

KW - race

U2 - 10.1016/j.rbmo.2015.05.015

DO - 10.1016/j.rbmo.2015.05.015

M3 - Article

C2 - 26208448

VL - 31

SP - 356

EP - 363

JO - Reproductive BioMedicine Online

JF - Reproductive BioMedicine Online

SN - 1472-6483

IS - 3

ER -