Invariant NKT Cells and Control of the Thymus Medulla

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Invariant NKT Cells and Control of the Thymus Medulla. / White, Andrea; Lucas, Beth; Jenkinson, William; Anderson, Graham.

In: Journal of Immunology, Vol. 200, No. 10, 15.05.2018, p. 3333-3339.

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@article{1f825b3cb8e8413389d84d9f18270b0e,
title = "Invariant NKT Cells and Control of the Thymus Medulla",
abstract = "Most αβ T cells that form in the thymus are generated during mainstream conventional thymocyte development and involve the generation and selection of a diverse αβ TCR repertoire that recognizes self-peptide/MHC complexes. Additionally, the thymus also supports the production of T cell subsets that express αβ TCRs but display unique developmental and functional features distinct from conventional αβ T cells. These include multiple lineages of CD1d-restricted invariant NKT (iNKT) cells that express an invariant αβ TCR, branch off from mainstream thymocytes at the CD4+CD8+ stage, and are potent producers of polarizing cytokines. Importantly, and despite their differences, iNKT cells and conventional αβ T cells share common requirements for thymic epithelial microenvironments during their development. Moreover, emerging evidence suggests that constitutive cytokine production by iNKT cells influences both conventional thymocyte development and the intrathymic formation of additional innate CD8+ αβ T cells with memory-like properties. In this article, we review evidence for an intrathymic innate lymphocyte network in which iNKT cells play key roles in multiple aspects of thymus function.",
author = "Andrea White and Beth Lucas and William Jenkinson and Graham Anderson",
note = "Copyright {\textcopyright} 2018 by The American Association of Immunologists, Inc.",
year = "2018",
month = may,
day = "15",
doi = "10.4049/jimmunol.1800120",
language = "English",
volume = "200",
pages = "3333--3339",
journal = "Journal of Immunology",
issn = "0022-1767",
publisher = "American Association of Immunologists",
number = "10",

}

RIS

TY - JOUR

T1 - Invariant NKT Cells and Control of the Thymus Medulla

AU - White, Andrea

AU - Lucas, Beth

AU - Jenkinson, William

AU - Anderson, Graham

N1 - Copyright © 2018 by The American Association of Immunologists, Inc.

PY - 2018/5/15

Y1 - 2018/5/15

N2 - Most αβ T cells that form in the thymus are generated during mainstream conventional thymocyte development and involve the generation and selection of a diverse αβ TCR repertoire that recognizes self-peptide/MHC complexes. Additionally, the thymus also supports the production of T cell subsets that express αβ TCRs but display unique developmental and functional features distinct from conventional αβ T cells. These include multiple lineages of CD1d-restricted invariant NKT (iNKT) cells that express an invariant αβ TCR, branch off from mainstream thymocytes at the CD4+CD8+ stage, and are potent producers of polarizing cytokines. Importantly, and despite their differences, iNKT cells and conventional αβ T cells share common requirements for thymic epithelial microenvironments during their development. Moreover, emerging evidence suggests that constitutive cytokine production by iNKT cells influences both conventional thymocyte development and the intrathymic formation of additional innate CD8+ αβ T cells with memory-like properties. In this article, we review evidence for an intrathymic innate lymphocyte network in which iNKT cells play key roles in multiple aspects of thymus function.

AB - Most αβ T cells that form in the thymus are generated during mainstream conventional thymocyte development and involve the generation and selection of a diverse αβ TCR repertoire that recognizes self-peptide/MHC complexes. Additionally, the thymus also supports the production of T cell subsets that express αβ TCRs but display unique developmental and functional features distinct from conventional αβ T cells. These include multiple lineages of CD1d-restricted invariant NKT (iNKT) cells that express an invariant αβ TCR, branch off from mainstream thymocytes at the CD4+CD8+ stage, and are potent producers of polarizing cytokines. Importantly, and despite their differences, iNKT cells and conventional αβ T cells share common requirements for thymic epithelial microenvironments during their development. Moreover, emerging evidence suggests that constitutive cytokine production by iNKT cells influences both conventional thymocyte development and the intrathymic formation of additional innate CD8+ αβ T cells with memory-like properties. In this article, we review evidence for an intrathymic innate lymphocyte network in which iNKT cells play key roles in multiple aspects of thymus function.

U2 - 10.4049/jimmunol.1800120

DO - 10.4049/jimmunol.1800120

M3 - Review article

C2 - 29735644

VL - 200

SP - 3333

EP - 3339

JO - Journal of Immunology

JF - Journal of Immunology

SN - 0022-1767

IS - 10

ER -