Intramolecular DNA coiling mediated by metallo-supramolecular cylinders: differential binding of P and M helical enantiomers

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Intramolecular DNA coiling mediated by metallo-supramolecular cylinders: differential binding of P and M helical enantiomers. / Meistermann, I; Moreno, V; Prieto, MJ; Molderheim, E; Sletten, E; Khalid, S; Rodger, PM; Peberdy, JC; Isaac, CJ; Rodger, A; Hannon, Michael.

In: National Academy of Sciences. Proceedings, Vol. 99, 01.01.2002, p. 5069-5074.

Research output: Contribution to journalArticle

Harvard

Meistermann, I, Moreno, V, Prieto, MJ, Molderheim, E, Sletten, E, Khalid, S, Rodger, PM, Peberdy, JC, Isaac, CJ, Rodger, A & Hannon, M 2002, 'Intramolecular DNA coiling mediated by metallo-supramolecular cylinders: differential binding of P and M helical enantiomers', National Academy of Sciences. Proceedings, vol. 99, pp. 5069-5074. https://doi.org/10.1073/pnas.062634499

APA

Meistermann, I., Moreno, V., Prieto, MJ., Molderheim, E., Sletten, E., Khalid, S., Rodger, PM., Peberdy, JC., Isaac, CJ., Rodger, A., & Hannon, M. (2002). Intramolecular DNA coiling mediated by metallo-supramolecular cylinders: differential binding of P and M helical enantiomers. National Academy of Sciences. Proceedings, 99, 5069-5074. https://doi.org/10.1073/pnas.062634499

Vancouver

Author

Meistermann, I ; Moreno, V ; Prieto, MJ ; Molderheim, E ; Sletten, E ; Khalid, S ; Rodger, PM ; Peberdy, JC ; Isaac, CJ ; Rodger, A ; Hannon, Michael. / Intramolecular DNA coiling mediated by metallo-supramolecular cylinders: differential binding of P and M helical enantiomers. In: National Academy of Sciences. Proceedings. 2002 ; Vol. 99. pp. 5069-5074.

Bibtex

@article{fc51b52bbfc44488902173f71e4dd8e4,
title = "Intramolecular DNA coiling mediated by metallo-supramolecular cylinders: differential binding of P and M helical enantiomers",
abstract = "We have designed a synthetic tetracationic metallo-supramolecular cylinder that targets the major groove of DNA with a binding constant in excess of 10(7) M(-1) and induces DNA bending and intramolecular coiling. The two enantiomers of the helical molecule bind differently to DNA and have different structural effects. We report the characterization of the interactions by a range of biophysical techniques. The M helical cylinder binds to the major groove and induces dramatic intramolecular coiling. The DNA bending is less dramatic for the P enantiomer.",
author = "I Meistermann and V Moreno and MJ Prieto and E Molderheim and E Sletten and S Khalid and PM Rodger and JC Peberdy and CJ Isaac and A Rodger and Michael Hannon",
year = "2002",
month = jan,
day = "1",
doi = "10.1073/pnas.062634499",
language = "English",
volume = "99",
pages = "5069--5074",
journal = "Proceedings of the National Academy of Sciences",
issn = "1091-6490",
publisher = "National Academy of Sciences",

}

RIS

TY - JOUR

T1 - Intramolecular DNA coiling mediated by metallo-supramolecular cylinders: differential binding of P and M helical enantiomers

AU - Meistermann, I

AU - Moreno, V

AU - Prieto, MJ

AU - Molderheim, E

AU - Sletten, E

AU - Khalid, S

AU - Rodger, PM

AU - Peberdy, JC

AU - Isaac, CJ

AU - Rodger, A

AU - Hannon, Michael

PY - 2002/1/1

Y1 - 2002/1/1

N2 - We have designed a synthetic tetracationic metallo-supramolecular cylinder that targets the major groove of DNA with a binding constant in excess of 10(7) M(-1) and induces DNA bending and intramolecular coiling. The two enantiomers of the helical molecule bind differently to DNA and have different structural effects. We report the characterization of the interactions by a range of biophysical techniques. The M helical cylinder binds to the major groove and induces dramatic intramolecular coiling. The DNA bending is less dramatic for the P enantiomer.

AB - We have designed a synthetic tetracationic metallo-supramolecular cylinder that targets the major groove of DNA with a binding constant in excess of 10(7) M(-1) and induces DNA bending and intramolecular coiling. The two enantiomers of the helical molecule bind differently to DNA and have different structural effects. We report the characterization of the interactions by a range of biophysical techniques. The M helical cylinder binds to the major groove and induces dramatic intramolecular coiling. The DNA bending is less dramatic for the P enantiomer.

UR - http://www.scopus.com/inward/record.url?scp=17444409376&partnerID=8YFLogxK

U2 - 10.1073/pnas.062634499

DO - 10.1073/pnas.062634499

M3 - Article

C2 - 11959957

VL - 99

SP - 5069

EP - 5074

JO - Proceedings of the National Academy of Sciences

JF - Proceedings of the National Academy of Sciences

SN - 1091-6490

ER -